Vitamin D status of socio-economically deprived children in Kabul, Afghanistan

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Vitamin D status of socio-economically deprived children in Kabul, Afghanistan. / Manaseki-Holland, Semira; Mughal, MZ; Bhutta, Z; Shams, MQ.

In: International Journal for Vitamin and Nutrition Research, Vol. 78, No. 1, 01.01.2008, p. 16-20.

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@article{109b13ac7f5d460498d6e06d22c73eb8,
title = "Vitamin D status of socio-economically deprived children in Kabul, Afghanistan",
abstract = "Background: Cultural, environmental, and diet-related factors were postulated to lead to a high prevalence of vitamin D deficiency in Kabul's socioeconomically deprived children under 5 years of age. We investigated the prevalence of plasma 25-hydroxyvitamin D (25-OHD) deficiency in such a group. Methods: Children between 6 months and up to 5 years of age were randomly sampled in the Chindawal area of Kabul in January 2005. Plasma samples were frozen to below -20 degrees C and 25(OH)D3 concentrations estimated by high-pressure liquid chromatography. Results: For all 107 children tested, the median plasma 25(OH)D concentration was 5 ng/mL with a range of 2-24 ng/mL; 73% had concentrations of <8 ng/mL; 13 other samples were not analyzed due to insufficiency of plasma, staff, or technical problems. About 35 others approached either did not give consent or blood could not be obtained. Conclusions: This study was conducted in a high-risk population at a peak season for vitamin D deficiency. We conclude that this population of children living in Kabul to be at great risk of developing vitamin D deficiency, rickets, and other possible immunological effects of deficiency.",
keywords = "children less than 5 years, vitamin D concentrations, vitamin D deficiency, Afghanistan",
author = "Semira Manaseki-Holland and MZ Mughal and Z Bhutta and MQ Shams",
year = "2008",
month = jan,
day = "1",
doi = "10.1024/0300-9831.78.1.16",
language = "English",
volume = "78",
pages = "16--20",
journal = "International Journal for Vitamin and Nutrition Research",
issn = "0300-9831",
publisher = "Hogrefe",
number = "1",

}

RIS

TY - JOUR

T1 - Vitamin D status of socio-economically deprived children in Kabul, Afghanistan

AU - Manaseki-Holland, Semira

AU - Mughal, MZ

AU - Bhutta, Z

AU - Shams, MQ

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background: Cultural, environmental, and diet-related factors were postulated to lead to a high prevalence of vitamin D deficiency in Kabul's socioeconomically deprived children under 5 years of age. We investigated the prevalence of plasma 25-hydroxyvitamin D (25-OHD) deficiency in such a group. Methods: Children between 6 months and up to 5 years of age were randomly sampled in the Chindawal area of Kabul in January 2005. Plasma samples were frozen to below -20 degrees C and 25(OH)D3 concentrations estimated by high-pressure liquid chromatography. Results: For all 107 children tested, the median plasma 25(OH)D concentration was 5 ng/mL with a range of 2-24 ng/mL; 73% had concentrations of <8 ng/mL; 13 other samples were not analyzed due to insufficiency of plasma, staff, or technical problems. About 35 others approached either did not give consent or blood could not be obtained. Conclusions: This study was conducted in a high-risk population at a peak season for vitamin D deficiency. We conclude that this population of children living in Kabul to be at great risk of developing vitamin D deficiency, rickets, and other possible immunological effects of deficiency.

AB - Background: Cultural, environmental, and diet-related factors were postulated to lead to a high prevalence of vitamin D deficiency in Kabul's socioeconomically deprived children under 5 years of age. We investigated the prevalence of plasma 25-hydroxyvitamin D (25-OHD) deficiency in such a group. Methods: Children between 6 months and up to 5 years of age were randomly sampled in the Chindawal area of Kabul in January 2005. Plasma samples were frozen to below -20 degrees C and 25(OH)D3 concentrations estimated by high-pressure liquid chromatography. Results: For all 107 children tested, the median plasma 25(OH)D concentration was 5 ng/mL with a range of 2-24 ng/mL; 73% had concentrations of <8 ng/mL; 13 other samples were not analyzed due to insufficiency of plasma, staff, or technical problems. About 35 others approached either did not give consent or blood could not be obtained. Conclusions: This study was conducted in a high-risk population at a peak season for vitamin D deficiency. We conclude that this population of children living in Kabul to be at great risk of developing vitamin D deficiency, rickets, and other possible immunological effects of deficiency.

KW - children less than 5 years

KW - vitamin D concentrations

KW - vitamin D deficiency

KW - Afghanistan

U2 - 10.1024/0300-9831.78.1.16

DO - 10.1024/0300-9831.78.1.16

M3 - Article

C2 - 18654949

VL - 78

SP - 16

EP - 20

JO - International Journal for Vitamin and Nutrition Research

JF - International Journal for Vitamin and Nutrition Research

SN - 0300-9831

IS - 1

ER -