Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China

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Vitamin D status in women with dichorionic twin pregnancies and their neonates : a pilot study in China. / Li, Xin; Yu, Jiaxiao ; Wen, Li; Li, Qingshu; Yan, Jianying; Tian, Jing; Tong, Chao; Tong, Qi; Qi, Hongbo; Saffery, Richard; Kilby, Mark; Baker, Philip N.

In: BMC pregnancy and childbirth, Vol. 21, 279, 08.04.2021.

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APA

Li, X., Yu, J., Wen, L., Li, Q., Yan, J., Tian, J., Tong, C., Tong, Q., Qi, H., Saffery, R., Kilby, M., & Baker, P. N. (2021). Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China. BMC pregnancy and childbirth, 21, [279]. https://doi.org/10.1186/s12884-021-03707-7

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Author

Li, Xin ; Yu, Jiaxiao ; Wen, Li ; Li, Qingshu ; Yan, Jianying ; Tian, Jing ; Tong, Chao ; Tong, Qi ; Qi, Hongbo ; Saffery, Richard ; Kilby, Mark ; Baker, Philip N. / Vitamin D status in women with dichorionic twin pregnancies and their neonates : a pilot study in China. In: BMC pregnancy and childbirth. 2021 ; Vol. 21.

Bibtex

@article{05ada5b5d3d140aca67c19c21d42e33a,
title = "Vitamin D status in women with dichorionic twin pregnancies and their neonates: a pilot study in China",
abstract = "BackgroundVitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth.MethodsA prospective subcohort investigation was carried out among 72 dichorionic, diamniotic twin-pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester, and cord blood was collected from neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected.ResultsThe average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficient and 20.8% insufficient, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficient. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the cotwin birthweight discordance (beta-value: -2.67, 95% CI: − 5.11, − 0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at 6 months than those of mothers with vitamin D sufficiency.ConclusionsTwin neonates were at high risk of vitamin D deficiency, although their mothers{\textquoteright} vitamin D deficiency partially improved. Higher maternal vitamin D levels were associated with smaller discordance of cotwin birthweight.Trial registrationChinese Clinical Trial Registry ChiCTR-OOC-16008203, 1st April 2016.",
author = "Xin Li and Jiaxiao Yu and Li Wen and Qingshu Li and Jianying Yan and Jing Tian and Chao Tong and Qi Tong and Hongbo Qi and Richard Saffery and Mark Kilby and Baker, {Philip N.}",
year = "2021",
month = apr,
day = "8",
doi = "10.1186/s12884-021-03707-7",
language = "English",
volume = "21",
journal = "BMC pregnancy and childbirth",
issn = "1471-2393",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Vitamin D status in women with dichorionic twin pregnancies and their neonates

T2 - a pilot study in China

AU - Li, Xin

AU - Yu, Jiaxiao

AU - Wen, Li

AU - Li, Qingshu

AU - Yan, Jianying

AU - Tian, Jing

AU - Tong, Chao

AU - Tong, Qi

AU - Qi, Hongbo

AU - Saffery, Richard

AU - Kilby, Mark

AU - Baker, Philip N.

PY - 2021/4/8

Y1 - 2021/4/8

N2 - BackgroundVitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth.MethodsA prospective subcohort investigation was carried out among 72 dichorionic, diamniotic twin-pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester, and cord blood was collected from neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected.ResultsThe average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficient and 20.8% insufficient, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficient. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the cotwin birthweight discordance (beta-value: -2.67, 95% CI: − 5.11, − 0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at 6 months than those of mothers with vitamin D sufficiency.ConclusionsTwin neonates were at high risk of vitamin D deficiency, although their mothers’ vitamin D deficiency partially improved. Higher maternal vitamin D levels were associated with smaller discordance of cotwin birthweight.Trial registrationChinese Clinical Trial Registry ChiCTR-OOC-16008203, 1st April 2016.

AB - BackgroundVitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth.MethodsA prospective subcohort investigation was carried out among 72 dichorionic, diamniotic twin-pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester, and cord blood was collected from neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected.ResultsThe average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficient and 20.8% insufficient, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficient. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the cotwin birthweight discordance (beta-value: -2.67, 95% CI: − 5.11, − 0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at 6 months than those of mothers with vitamin D sufficiency.ConclusionsTwin neonates were at high risk of vitamin D deficiency, although their mothers’ vitamin D deficiency partially improved. Higher maternal vitamin D levels were associated with smaller discordance of cotwin birthweight.Trial registrationChinese Clinical Trial Registry ChiCTR-OOC-16008203, 1st April 2016.

U2 - 10.1186/s12884-021-03707-7

DO - 10.1186/s12884-021-03707-7

M3 - Article

VL - 21

JO - BMC pregnancy and childbirth

JF - BMC pregnancy and childbirth

SN - 1471-2393

M1 - 279

ER -