Abstract
In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. However, the biological significance of the expression of the VDR in different tissues is not fully understood, and the role of vitamin D in extraskeletal health has been a matter of debate. This report summarizes recent research on the roles for vitamin D in cancer, immunity and autoimmune diseases, cardiovascular and respiratory health, pregnancy, obesity, erythropoiesis, diabetes, muscle function, and aging.
Original language | English |
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Pages (from-to) | 45-58 |
Number of pages | 14 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1287 |
DOIs | |
Publication status | Published - May 2013 |
Bibliographical note
© 2013 New York Academy of Sciences.Keywords
- Adult
- Animals
- Autoimmune Diseases
- Calcium Signaling
- Cardiovascular Diseases
- Cognition Disorders
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Erythropoiesis
- Female
- Humans
- Immune System
- Infant
- Lactation
- Male
- Mice
- Nutritional Requirements
- Obesity
- Organ Specificity
- Pregnancy
- Pulmonary Disease, Chronic Obstructive
- Randomized Controlled Trials as Topic
- Receptors, Calcitriol
- Vitamin D
- Vitamin D Deficiency