Viral Interactions with PDZ Domain-Containing Proteins - An Oncogenic Trait?

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Viral Interactions with PDZ Domain-Containing Proteins - An Oncogenic Trait? / Roberts, Sally; James, Claire.

In: Pathogens, Vol. 5, No. 8, 18.01.2016.

Research output: Contribution to journalReview articlepeer-review

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@article{1d5c1c27bcd24c4aaa3ce428e111b887,
title = "Viral Interactions with PDZ Domain-Containing Proteins - An Oncogenic Trait?",
abstract = "Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins containing PSD95/ DLG/ZO-1 (PDZ) interaction modules. In many cases (but not always), the viruses have evolved to bind the PDZ domains using the same short linear peptide motifs found in host protein-PDZ interactions, and in some cases regulate the interactions in a similar fashion by phosphorylation. What is striking is that the diverse viruses target a common subset of PDZ proteins that are intimately involved in controlling cell polarity and the structure and function of intercellular junctions, including tight junctions. Cell polarity is fundamental to the control of cell proliferation and cell survival and disruption of polarity and the signal transduction pathways involved is a key event in tumourigenesis. This review focuses on the oncogenic viruses and the role of targeting PDZ proteins in the virus life cycle and the contribution of virus-PDZ protein interactions to virus-mediated oncogenesis. We highlight how many of the viral associations with PDZ proteins lead to deregulation of PI3K/AKT signalling, benefitting virus replication but as a consequence also contributing to oncogenesis.",
keywords = "oncogenic viruses, PDZ proteins, PI3K/AKT signalling, cell polarity, HPV E6, adenovirus E4ORF1, DLG1, SCRIB, tight junctions",
author = "Sally Roberts and Claire James",
year = "2016",
month = jan,
day = "18",
doi = "10.3390/pathogens5010008",
language = "English",
volume = "5",
journal = "Pathogens",
issn = "2076-0817",
publisher = "MDPI",
number = "8",

}

RIS

TY - JOUR

T1 - Viral Interactions with PDZ Domain-Containing Proteins - An Oncogenic Trait?

AU - Roberts, Sally

AU - James, Claire

PY - 2016/1/18

Y1 - 2016/1/18

N2 - Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins containing PSD95/ DLG/ZO-1 (PDZ) interaction modules. In many cases (but not always), the viruses have evolved to bind the PDZ domains using the same short linear peptide motifs found in host protein-PDZ interactions, and in some cases regulate the interactions in a similar fashion by phosphorylation. What is striking is that the diverse viruses target a common subset of PDZ proteins that are intimately involved in controlling cell polarity and the structure and function of intercellular junctions, including tight junctions. Cell polarity is fundamental to the control of cell proliferation and cell survival and disruption of polarity and the signal transduction pathways involved is a key event in tumourigenesis. This review focuses on the oncogenic viruses and the role of targeting PDZ proteins in the virus life cycle and the contribution of virus-PDZ protein interactions to virus-mediated oncogenesis. We highlight how many of the viral associations with PDZ proteins lead to deregulation of PI3K/AKT signalling, benefitting virus replication but as a consequence also contributing to oncogenesis.

AB - Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins containing PSD95/ DLG/ZO-1 (PDZ) interaction modules. In many cases (but not always), the viruses have evolved to bind the PDZ domains using the same short linear peptide motifs found in host protein-PDZ interactions, and in some cases regulate the interactions in a similar fashion by phosphorylation. What is striking is that the diverse viruses target a common subset of PDZ proteins that are intimately involved in controlling cell polarity and the structure and function of intercellular junctions, including tight junctions. Cell polarity is fundamental to the control of cell proliferation and cell survival and disruption of polarity and the signal transduction pathways involved is a key event in tumourigenesis. This review focuses on the oncogenic viruses and the role of targeting PDZ proteins in the virus life cycle and the contribution of virus-PDZ protein interactions to virus-mediated oncogenesis. We highlight how many of the viral associations with PDZ proteins lead to deregulation of PI3K/AKT signalling, benefitting virus replication but as a consequence also contributing to oncogenesis.

KW - oncogenic viruses

KW - PDZ proteins

KW - PI3K/AKT signalling

KW - cell polarity

KW - HPV E6

KW - adenovirus E4ORF1

KW - DLG1

KW - SCRIB

KW - tight junctions

U2 - 10.3390/pathogens5010008

DO - 10.3390/pathogens5010008

M3 - Review article

VL - 5

JO - Pathogens

JF - Pathogens

SN - 2076-0817

IS - 8

ER -