Ventral tegmental dopamine dysregulation prevents appetitive memory destabilization
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
Abstract
Through the process of reconsolidation, memories can be updated to maintain their relevance. To reconsolidate, a memory must first be destabilized in a process that we have hypothesized is initiated by a prediction error signal. Here we demonstrate that dysregulation of ventral tegmental area (VTA) signaling, which is thought to mediate prediction errors, prevented the destabilization of an appetitive goal-tracking memory in rats. We additionally show that intra-VTA infusion of either the competitive NMDA antagonist AP5 or the noncompetitive NMDA antagonist MK-801 does not selectively disrupt reconsolidation, indicating that the VTA may not be an important neural locus of reconsolidation-related neural plasticity.
Details
Original language | English |
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Pages (from-to) | 14205-10 |
Number of pages | 6 |
Journal | The Journal of Neuroscience |
Volume | 33 |
Issue number | 35 |
Publication status | Published - 28 Aug 2013 |