Ventral tegmental dopamine dysregulation prevents appetitive memory destabilization

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Colleges, School and Institutes

Abstract

Through the process of reconsolidation, memories can be updated to maintain their relevance. To reconsolidate, a memory must first be destabilized in a process that we have hypothesized is initiated by a prediction error signal. Here we demonstrate that dysregulation of ventral tegmental area (VTA) signaling, which is thought to mediate prediction errors, prevented the destabilization of an appetitive goal-tracking memory in rats. We additionally show that intra-VTA infusion of either the competitive NMDA antagonist AP5 or the noncompetitive NMDA antagonist MK-801 does not selectively disrupt reconsolidation, indicating that the VTA may not be an important neural locus of reconsolidation-related neural plasticity.

Details

Original languageEnglish
Pages (from-to)14205-10
Number of pages6
JournalThe Journal of Neuroscience
Volume33
Issue number35
Publication statusPublished - 28 Aug 2013