Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium

Research output: Contribution to journalArticle

Authors

  • G McNab
  • M Salmi
  • S Jalkanen
  • D H Adams

Abstract

Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, it could play a role in regulating T-cell recruitment to the liver. The aim of this study was to investigate the distribution of VAP-1 expression in human liver and the ability of VAP-1 to support T-cell binding to hepatic endothelium in vitro.

Details

Original languageEnglish
Pages (from-to)522-8
Number of pages7
JournalGastroenterology
Volume110
Issue number2
Publication statusPublished - Feb 1996

Keywords

  • Cell Adhesion, Endothelium, Endothelium, Vascular, Graft Rejection, Humans, Immunohistochemistry, Liver, Liver Cirrhosis, Biliary, Liver Transplantation, T-Lymphocytes, Vascular Cell Adhesion Molecule-1