Abstract
Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, it could play a role in regulating T-cell recruitment to the liver. The aim of this study was to investigate the distribution of VAP-1 expression in human liver and the ability of VAP-1 to support T-cell binding to hepatic endothelium in vitro.
Original language | English |
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Pages (from-to) | 522-8 |
Number of pages | 7 |
Journal | Gastroenterology |
Volume | 110 |
Issue number | 2 |
Publication status | Published - Feb 1996 |
Keywords
- Cell Adhesion
- Endothelium
- Endothelium, Vascular
- Graft Rejection
- Humans
- Immunohistochemistry
- Liver
- Liver Cirrhosis, Biliary
- Liver Transplantation
- T-Lymphocytes
- Vascular Cell Adhesion Molecule-1