TY - JOUR
T1 - Variations of collagen-encoding genes are associated with exercise-induced muscle damage
AU - Baumert, P.
AU - Consortium, G-REX
AU - Stewart, C. E.
AU - Lake, M. J.
AU - Drust, Barry
AU - Erskine, R. M.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - We investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I (COL1A1, rs2249492; rs1800012), type II (COL2A1, rs2070739) and type V (COL5A1, rs12722) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were genotyped for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers (rs1800012) and (major) T-allele homozygotes (rs2249492) were generally weaker (p$0.019); and (minor) A-allele carriers of COL2A1 (p=0.002) and (major) T-allele carriers COL5A1 (p=0.004) SNPs reported greater muscle soreness, all compared to their respective major (rs1800012; rs2070739) and minor (rs2249492; rs12722) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle?s mechanical properties.
AB - We investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I (COL1A1, rs2249492; rs1800012), type II (COL2A1, rs2070739) and type V (COL5A1, rs12722) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were genotyped for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers (rs1800012) and (major) T-allele homozygotes (rs2249492) were generally weaker (p$0.019); and (minor) A-allele carriers of COL2A1 (p=0.002) and (major) T-allele carriers COL5A1 (p=0.004) SNPs reported greater muscle soreness, all compared to their respective major (rs1800012; rs2070739) and minor (rs2249492; rs12722) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle?s mechanical properties.
UR - http://researchonline.ljmu.ac.uk/id/eprint/8696/
U2 - 10.1152/physiolgenomics.00145.2017
DO - 10.1152/physiolgenomics.00145.2017
M3 - Article
SN - 1094-8341
VL - 50
SP - 691
EP - 693
JO - Physiological Genomics
JF - Physiological Genomics
IS - 9
ER -