TY - JOUR
T1 - Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
AU - Green, EK
AU - Grozeva, D
AU - Moskvina, V
AU - Hamshere, ML
AU - Jones, Ian
AU - Jones, Lisa
AU - Forty, L
AU - Caesar, S
AU - Gordon-Smith, Katherine
AU - Fraser, C
AU - Russell, E
AU - St Clair, D
AU - Young, AH
AU - Ferrier, N
AU - Farmer, A
AU - McGuffin, P
AU - Holmans, PA
AU - Owen, MJ
AU - O'Donovan, MC
AU - Craddock, N
PY - 2010/1/1
Y1 - 2010/1/1
N2 - We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).
AB - We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).
U2 - 10.1002/ajmg.b.31108
DO - 10.1002/ajmg.b.31108
M3 - Article
C2 - 20583128
VL - 153b
SP - 1347
EP - 1349
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
IS - 7
ER -