Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Research output: Contribution to journalArticle

Authors

  • EK Green
  • D Grozeva
  • V Moskvina
  • ML Hamshere
  • L Forty
  • S Caesar
  • C Fraser
  • E Russell
  • D St Clair
  • AH Young
  • N Ferrier
  • A Farmer
  • P McGuffin
  • PA Holmans
  • MJ Owen
  • MC O'Donovan
  • N Craddock

Colleges, School and Institutes

Abstract

We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Details

Original languageEnglish
Pages (from-to)1347-1349
Number of pages3
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume153b
Issue number7
Publication statusPublished - 1 Jan 2010