Variability in innate host immune responses to cryptococcosis

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) individuals, there is growing awareness of cryptococcal disease amongst non-immunocompromised patients. Whilst substantial progress has been made in understanding the pathogenicity of C. neoformans in HIV patients, prospective data on cryptococcosis outside the context of HIV remains lacking. Below we review how innate immune responses vary between hosts depending on immunological status, and discuss risk factors and predictors of disease outcome in different groups.

Details

Original languageEnglish
Article numbere180060
JournalMemorias do Instituto Oswaldo Cruz
Volume113
Issue number7
Publication statusPublished - 16 Apr 2018

Keywords

  • cryptococcus neoformans , host-pathogen interactions , innate immunity , infection , pathogenesis , macrophages , host variation