Vaccine-induced inflammation attenuates the vascular responses to mental stress

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@article{57d91fc94fd9422696e1cbc781423178,
title = "Vaccine-induced inflammation attenuates the vascular responses to mental stress",
abstract = "Inflammation is associated with poorer vascular function, with evidence to suggest that inflammation can also impair the vascular responses to mental stress. This study examined the effects of vaccine-induced inflammation on vascular responses to mental stress in healthy participants. Eighteen male participants completed two stress sessions: an inflammation condition having received a typhoid vaccination and a control (non-inflamed) condition. Tumor necrosis factor-alpha and interleukin-6 (p's<.001) increased following vaccination, confirming modest increases in inflammation. Mental stress increased blood flow, blood pressure, heart rate, and cardiac output in both conditions (all p's<.001), but the blood flow response to stress was attenuated having received the vaccination compared to the control condition (p's<.05). These results further implicate the interaction between inflammation and the vasculature as a mechanism through which stress may trigger myocardial infarction.",
author = "Paine, {Nicola J} and Christopher Ring and Bosch, {Jos A} and Drayson, {Mark T} and Sarah Aldred and {Veldhuijzen van Zanten}, {Jet J C S}",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = sep,
doi = "10.1016/j.ijpsycho.2014.06.016",
language = "English",
volume = "93",
pages = "340--8",
journal = "International journal of psychophysiology : official journal of the International Organization of Psychophysiology",
issn = "0167-8760",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Vaccine-induced inflammation attenuates the vascular responses to mental stress

AU - Paine, Nicola J

AU - Ring, Christopher

AU - Bosch, Jos A

AU - Drayson, Mark T

AU - Aldred, Sarah

AU - Veldhuijzen van Zanten, Jet J C S

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/9

Y1 - 2014/9

N2 - Inflammation is associated with poorer vascular function, with evidence to suggest that inflammation can also impair the vascular responses to mental stress. This study examined the effects of vaccine-induced inflammation on vascular responses to mental stress in healthy participants. Eighteen male participants completed two stress sessions: an inflammation condition having received a typhoid vaccination and a control (non-inflamed) condition. Tumor necrosis factor-alpha and interleukin-6 (p's<.001) increased following vaccination, confirming modest increases in inflammation. Mental stress increased blood flow, blood pressure, heart rate, and cardiac output in both conditions (all p's<.001), but the blood flow response to stress was attenuated having received the vaccination compared to the control condition (p's<.05). These results further implicate the interaction between inflammation and the vasculature as a mechanism through which stress may trigger myocardial infarction.

AB - Inflammation is associated with poorer vascular function, with evidence to suggest that inflammation can also impair the vascular responses to mental stress. This study examined the effects of vaccine-induced inflammation on vascular responses to mental stress in healthy participants. Eighteen male participants completed two stress sessions: an inflammation condition having received a typhoid vaccination and a control (non-inflamed) condition. Tumor necrosis factor-alpha and interleukin-6 (p's<.001) increased following vaccination, confirming modest increases in inflammation. Mental stress increased blood flow, blood pressure, heart rate, and cardiac output in both conditions (all p's<.001), but the blood flow response to stress was attenuated having received the vaccination compared to the control condition (p's<.05). These results further implicate the interaction between inflammation and the vasculature as a mechanism through which stress may trigger myocardial infarction.

U2 - 10.1016/j.ijpsycho.2014.06.016

DO - 10.1016/j.ijpsycho.2014.06.016

M3 - Article

C2 - 24998644

VL - 93

SP - 340

EP - 348

JO - International journal of psychophysiology : official journal of the International Organization of Psychophysiology

JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology

SN - 0167-8760

IS - 3

ER -