Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge

Research output: Contribution to journalArticle

Authors

  • M F Good
  • L Mateo
  • J Gardner
  • M H Gatei
  • R C Daniel
  • B V Meyers
  • M F Lavin
  • A Suhrbier

Colleges, School and Institutes

Abstract

The development of prophylactic vaccines against retroviral diseases has been impeded by the lack of obvious immune correlates for protection. Cytotoxic T-lymphocyte (CTL), CD4-lymphocyteS, chemokine and/or antibody responses have all been associated with protection against HIV and AIDS; however, effective and safe vaccination strategies remain elusive. Here we show that vaccination with a minimal ovine CTL peptide epitope identified within gp51 of the retrovirus bovine leukemia virus (BLV), consistently induced peptide-specific CTLs. Only sheep whose CTLs were also capable of recognizing retrovirus-infected cells were fully protected when challenged with BLV. This retrovirus displays limited sequence variation; thus, in the relative absence of confounding CTL escape variants, virus-specific CTLs targeting a single epitope were able to prevent the establishment of a latent retroviral infection.

Details

Original languageEnglish
Pages (from-to)1193-6
Number of pages4
JournalNature Medicine
Volume4
Issue number10
Publication statusPublished - Oct 1998

Keywords

  • Animals, Deltaretrovirus Infections, Leukemia Virus, Bovine, Leukemia, Lymphocytic, Chronic, B-Cell, Sheep, Sheep Diseases, T-Lymphocytes, Cytotoxic, Viral Envelope Proteins, Viral Vaccines, Virus Latency