Vaccinating healthcare workers against influenza to protect the vunerable - is it a good use of healthcare resources? A systematic review of the evidence and an economic evaluation

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@article{7712def382194583902ef43bbb4e02e0,
title = "Vaccinating healthcare workers against influenza to protect the vunerable - is it a good use of healthcare resources? A systematic review of the evidence and an economic evaluation",
abstract = "Influenza causes substantial mortality in high-risk groups despite targeted vaccination programmes. This paper considers whether it is worth vaccinating healthcare workers (HCWs) against influenza to protect high-risk patients in a series of systematic reviews and an economic evaluation. Eighteen studies are included. Vaccination was highly effective in HCWs, with minimal adverse effects. Two trials assessed patient mortality after vaccinating HCWs, both of which showed a reduction. Despite recommendations, less than 25% of HCW in Europe and the UK are vaccinated. Five studies looked at programmes to increase uptake; these produced increases of 5%-45%. Published economic evaluations did not include patient benefit; therefore, an economic evaluation using UK data was undertaken. In the base case, vaccination was cost saving (12 pound/vaccinee). In the most pessimistic scenario it cost 405 pound/life-year gained. Effective implementation should be a priority. (c) 2006 Elsevier Ltd. All rights reserved.",
keywords = "influenza vaccination, economic evaluation, healthcare workers, systematic review",
author = "Amanda Burls and Rachel Jordan and Pelham Barton and BL Wake and Esther Albon and B Olowokure and JI Hawker",
year = "2006",
month = may,
day = "8",
doi = "10.1016/j.vaccine.2005.12.043",
language = "English",
volume = "24",
pages = "4212--4221",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "19",

}

RIS

TY - JOUR

T1 - Vaccinating healthcare workers against influenza to protect the vunerable - is it a good use of healthcare resources? A systematic review of the evidence and an economic evaluation

AU - Burls, Amanda

AU - Jordan, Rachel

AU - Barton, Pelham

AU - Wake, BL

AU - Albon, Esther

AU - Olowokure, B

AU - Hawker, JI

PY - 2006/5/8

Y1 - 2006/5/8

N2 - Influenza causes substantial mortality in high-risk groups despite targeted vaccination programmes. This paper considers whether it is worth vaccinating healthcare workers (HCWs) against influenza to protect high-risk patients in a series of systematic reviews and an economic evaluation. Eighteen studies are included. Vaccination was highly effective in HCWs, with minimal adverse effects. Two trials assessed patient mortality after vaccinating HCWs, both of which showed a reduction. Despite recommendations, less than 25% of HCW in Europe and the UK are vaccinated. Five studies looked at programmes to increase uptake; these produced increases of 5%-45%. Published economic evaluations did not include patient benefit; therefore, an economic evaluation using UK data was undertaken. In the base case, vaccination was cost saving (12 pound/vaccinee). In the most pessimistic scenario it cost 405 pound/life-year gained. Effective implementation should be a priority. (c) 2006 Elsevier Ltd. All rights reserved.

AB - Influenza causes substantial mortality in high-risk groups despite targeted vaccination programmes. This paper considers whether it is worth vaccinating healthcare workers (HCWs) against influenza to protect high-risk patients in a series of systematic reviews and an economic evaluation. Eighteen studies are included. Vaccination was highly effective in HCWs, with minimal adverse effects. Two trials assessed patient mortality after vaccinating HCWs, both of which showed a reduction. Despite recommendations, less than 25% of HCW in Europe and the UK are vaccinated. Five studies looked at programmes to increase uptake; these produced increases of 5%-45%. Published economic evaluations did not include patient benefit; therefore, an economic evaluation using UK data was undertaken. In the base case, vaccination was cost saving (12 pound/vaccinee). In the most pessimistic scenario it cost 405 pound/life-year gained. Effective implementation should be a priority. (c) 2006 Elsevier Ltd. All rights reserved.

KW - influenza vaccination

KW - economic evaluation

KW - healthcare workers

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=33747625602&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2005.12.043

DO - 10.1016/j.vaccine.2005.12.043

M3 - Article

C2 - 16546308

VL - 24

SP - 4212

EP - 4221

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 19

ER -