Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function

Research output: Contribution to journalArticlepeer-review

Standard

Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. / Willie, C.K.; Colino, F.L.; Smith, K.J.; Smirl, J.D.; Ainslie, P.N.; Bailey, D.M.; Binsted, G.; Tzeng, Y.C.; Jones, L.W.; Haykowsky, M.J.; Bellapart, J.; Ogoh, S.; Day, T.A.; Lucas, S.J.; Eller, L.K.

In: Journal of Neuroscience Methods, Vol. 196, No. 2, 30.03.2011, p. 221-237.

Research output: Contribution to journalArticlepeer-review

Harvard

Willie, CK, Colino, FL, Smith, KJ, Smirl, JD, Ainslie, PN, Bailey, DM, Binsted, G, Tzeng, YC, Jones, LW, Haykowsky, MJ, Bellapart, J, Ogoh, S, Day, TA, Lucas, SJ & Eller, LK 2011, 'Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function', Journal of Neuroscience Methods, vol. 196, no. 2, pp. 221-237. https://doi.org/10.1016/j.jneumeth.2011.01.011

APA

Willie, C. K., Colino, F. L., Smith, K. J., Smirl, J. D., Ainslie, P. N., Bailey, D. M., Binsted, G., Tzeng, Y. C., Jones, L. W., Haykowsky, M. J., Bellapart, J., Ogoh, S., Day, T. A., Lucas, S. J., & Eller, L. K. (2011). Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. Journal of Neuroscience Methods, 196(2), 221-237. https://doi.org/10.1016/j.jneumeth.2011.01.011

Vancouver

Author

Willie, C.K. ; Colino, F.L. ; Smith, K.J. ; Smirl, J.D. ; Ainslie, P.N. ; Bailey, D.M. ; Binsted, G. ; Tzeng, Y.C. ; Jones, L.W. ; Haykowsky, M.J. ; Bellapart, J. ; Ogoh, S. ; Day, T.A. ; Lucas, S.J. ; Eller, L.K. / Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. In: Journal of Neuroscience Methods. 2011 ; Vol. 196, No. 2. pp. 221-237.

Bibtex

@article{062ebbfb56484c35a3db090f6d55789e,
title = "Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function",
abstract = "There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess cerebrovascular function. The brain is unique in its high energy and oxygen demand but limited capacity for energy storage that necessitates an effective means of regional blood delivery. The relative low cost, ease-of-use, non-invasiveness, and excellent temporal resolution of TCD make it an ideal tool for the examination of cerebrovascular function in both research and clinical settings. TCD is an efficient tool to access blood velocities within the cerebral vessels, cerebral autoregulation, cerebrovascular reactivity to CO2, and neurovascular coupling, in both physiological states and in pathological conditions such as stroke and head trauma. In this review, we provide: (1) an overview of TCD methodology with respect to other techniques; (2) a methodological synopsis of the cerebrovascular exam using TCD; (3) an overview of the physiological mechanisms involved in regulation of the cerebral blood flow; (4) the utility of TCD for assessment of cerebrovascular pathology; and (5) recommendations for the assessment of four critical and complimentary aspects of cerebrovascular function: intra-cranial blood flow velocity, cerebral autoregulation, cerebral reactivity, and neurovascular coupling. The integration of these regulatory mechanisms from an integrated systems perspective is discussed, and future research directions are explored.",
author = "C.K. Willie and F.L. Colino and K.J. Smith and J.D. Smirl and P.N. Ainslie and D.M. Bailey and G. Binsted and Y.C. Tzeng and L.W. Jones and M.J. Haykowsky and J. Bellapart and S. Ogoh and T.A. Day and S.J. Lucas and L.K. Eller",
year = "2011",
month = mar,
day = "30",
doi = "10.1016/j.jneumeth.2011.01.011",
language = "English",
volume = "196",
pages = "221--237",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function

AU - Willie, C.K.

AU - Colino, F.L.

AU - Smith, K.J.

AU - Smirl, J.D.

AU - Ainslie, P.N.

AU - Bailey, D.M.

AU - Binsted, G.

AU - Tzeng, Y.C.

AU - Jones, L.W.

AU - Haykowsky, M.J.

AU - Bellapart, J.

AU - Ogoh, S.

AU - Day, T.A.

AU - Lucas, S.J.

AU - Eller, L.K.

PY - 2011/3/30

Y1 - 2011/3/30

N2 - There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess cerebrovascular function. The brain is unique in its high energy and oxygen demand but limited capacity for energy storage that necessitates an effective means of regional blood delivery. The relative low cost, ease-of-use, non-invasiveness, and excellent temporal resolution of TCD make it an ideal tool for the examination of cerebrovascular function in both research and clinical settings. TCD is an efficient tool to access blood velocities within the cerebral vessels, cerebral autoregulation, cerebrovascular reactivity to CO2, and neurovascular coupling, in both physiological states and in pathological conditions such as stroke and head trauma. In this review, we provide: (1) an overview of TCD methodology with respect to other techniques; (2) a methodological synopsis of the cerebrovascular exam using TCD; (3) an overview of the physiological mechanisms involved in regulation of the cerebral blood flow; (4) the utility of TCD for assessment of cerebrovascular pathology; and (5) recommendations for the assessment of four critical and complimentary aspects of cerebrovascular function: intra-cranial blood flow velocity, cerebral autoregulation, cerebral reactivity, and neurovascular coupling. The integration of these regulatory mechanisms from an integrated systems perspective is discussed, and future research directions are explored.

AB - There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess cerebrovascular function. The brain is unique in its high energy and oxygen demand but limited capacity for energy storage that necessitates an effective means of regional blood delivery. The relative low cost, ease-of-use, non-invasiveness, and excellent temporal resolution of TCD make it an ideal tool for the examination of cerebrovascular function in both research and clinical settings. TCD is an efficient tool to access blood velocities within the cerebral vessels, cerebral autoregulation, cerebrovascular reactivity to CO2, and neurovascular coupling, in both physiological states and in pathological conditions such as stroke and head trauma. In this review, we provide: (1) an overview of TCD methodology with respect to other techniques; (2) a methodological synopsis of the cerebrovascular exam using TCD; (3) an overview of the physiological mechanisms involved in regulation of the cerebral blood flow; (4) the utility of TCD for assessment of cerebrovascular pathology; and (5) recommendations for the assessment of four critical and complimentary aspects of cerebrovascular function: intra-cranial blood flow velocity, cerebral autoregulation, cerebral reactivity, and neurovascular coupling. The integration of these regulatory mechanisms from an integrated systems perspective is discussed, and future research directions are explored.

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-79952537997&md5=3c579d82e6d264692851e9c1eecf2f4d

U2 - 10.1016/j.jneumeth.2011.01.011

DO - 10.1016/j.jneumeth.2011.01.011

M3 - Article

AN - SCOPUS:79952537997

VL - 196

SP - 221

EP - 237

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

IS - 2

ER -