Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function

Research output: Contribution to journalArticlepeer-review


  • C.K. Willie
  • F.L. Colino
  • K.J. Smith
  • J.D. Smirl
  • P.N. Ainslie
  • D.M. Bailey
  • G. Binsted
  • Y.C. Tzeng
  • L.W. Jones
  • M.J. Haykowsky
  • J. Bellapart
  • S. Ogoh
  • T.A. Day
  • L.K. Eller

Colleges, School and Institutes

External organisations

  • University of Otago
  • University of British Columbia
  • University of Alberta
  • Duke University
  • Science and Sport, University of Glamorgan
  • Intensive Care Department
  • Toyo University
  • Mount Royal University
  • University of Calgary


There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess cerebrovascular function. The brain is unique in its high energy and oxygen demand but limited capacity for energy storage that necessitates an effective means of regional blood delivery. The relative low cost, ease-of-use, non-invasiveness, and excellent temporal resolution of TCD make it an ideal tool for the examination of cerebrovascular function in both research and clinical settings. TCD is an efficient tool to access blood velocities within the cerebral vessels, cerebral autoregulation, cerebrovascular reactivity to CO2, and neurovascular coupling, in both physiological states and in pathological conditions such as stroke and head trauma. In this review, we provide: (1) an overview of TCD methodology with respect to other techniques; (2) a methodological synopsis of the cerebrovascular exam using TCD; (3) an overview of the physiological mechanisms involved in regulation of the cerebral blood flow; (4) the utility of TCD for assessment of cerebrovascular pathology; and (5) recommendations for the assessment of four critical and complimentary aspects of cerebrovascular function: intra-cranial blood flow velocity, cerebral autoregulation, cerebral reactivity, and neurovascular coupling. The integration of these regulatory mechanisms from an integrated systems perspective is discussed, and future research directions are explored.


Original languageEnglish
Pages (from-to)221-237
Number of pages17
JournalJournal of Neuroscience Methods
Issue number2
Publication statusPublished - 30 Mar 2011