Using Ex Vivo Liver Organ Cultures to Measure Lymphocyte Trafficking
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Colleges, School and Institutes
- Centre for Liver Research, Immunity and Immunotherapy, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK.
Lymphocyte recruitment to different organs, and even alternate anatomical regions within the same organ, is differentially regulated. Key combinations of adhesion molecules and chemokines govern compartmentalization, and these can change depending upon the nature and duration of tissue injury. We are interested in understanding lymphocyte recruitment to the liver during human disease, and thus need models of the liver inflammatory milieu that are as representative as possible. Here we describe the use of precision cut liver slices as models of disease.
|Title of host publication||T-Cell Trafficking:|
|Subtitle of host publication||Methods and Protocols|
|Editors||George Edward Rainger, Helen M. Mcgettrick|
|Publication status||Published - 28 Mar 2017|
|Name||Methods in Molecular Biology|
- Journal Article, antibody , human , inflammation , liver , lymphocyte , organ culture