Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts

Research output: Contribution to journalArticle

Standard

Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts. / Bakir, M; Dosanjh, Davinder; Deeks, Jonathan; Soysal, A; Millington, KA; Efe, S; Aslan, Y; Polat, D; Kodalli, N; Yagci, A; Barlan, I; Bahceciler, N; Demiralp, EE; Lalvani, A.

In: Clinical Infectious Diseases, Vol. 48, No. 3, 01.02.2009, p. 302-312.

Research output: Contribution to journalArticle

Harvard

Bakir, M, Dosanjh, D, Deeks, J, Soysal, A, Millington, KA, Efe, S, Aslan, Y, Polat, D, Kodalli, N, Yagci, A, Barlan, I, Bahceciler, N, Demiralp, EE & Lalvani, A 2009, 'Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts', Clinical Infectious Diseases, vol. 48, no. 3, pp. 302-312. https://doi.org/10.1086/595847

APA

Bakir, M., Dosanjh, D., Deeks, J., Soysal, A., Millington, KA., Efe, S., Aslan, Y., Polat, D., Kodalli, N., Yagci, A., Barlan, I., Bahceciler, N., Demiralp, EE., & Lalvani, A. (2009). Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts. Clinical Infectious Diseases, 48(3), 302-312. https://doi.org/10.1086/595847

Vancouver

Author

Bakir, M ; Dosanjh, Davinder ; Deeks, Jonathan ; Soysal, A ; Millington, KA ; Efe, S ; Aslan, Y ; Polat, D ; Kodalli, N ; Yagci, A ; Barlan, I ; Bahceciler, N ; Demiralp, EE ; Lalvani, A. / Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts. In: Clinical Infectious Diseases. 2009 ; Vol. 48, No. 3. pp. 302-312.

Bibtex

@article{8acf466e170d4b1f80098c5de969b362,
title = "Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts",
abstract = "Background. Treatment of recent tuberculosis infection in children aged ! 2 years is essential, because of high risk of progression to disease, but diagnosis is hindered by the inaccuracy of the tuberculin skin test (TST). More-accurate T cell-based tests of infection could enhance diagnosis by optimizing interpretation of the TST results. Methods. A total of 979 child tuberculosis contacts in Istanbul underwent the TST and enzyme-linked immunospot assay. Using enzyme-linked immunospot test results as a reference standard, we assessed the effect of age and bacille Calmette-Guerin ( BCG) vaccination on the sensitivity and specificity of the TST, and we computed the optimal TST cutoff points, using receiver operating characteristic curves. Results. With a TST cutoff point of >= 10 mm, the sensitivity of the TST was 66% for children aged = 2 years, and overall accuracy was low for children with 1 BCG scar. Conclusions. Negative results of the TST cannot exclude tuberculosis infection for child tuberculosis contacts aged = 2 years, the accuracy of the TST can be improved by adjustment of cutoff points for BCG-vaccinated children but remains poor for children with >1 BCG scar. This methodology can define optimal TST cutoff points for diagnosis of tuberculosis infection tailored to target populations.",
author = "M Bakir and Davinder Dosanjh and Jonathan Deeks and A Soysal and KA Millington and S Efe and Y Aslan and D Polat and N Kodalli and A Yagci and I Barlan and N Bahceciler and EE Demiralp and A Lalvani",
year = "2009",
month = feb,
day = "1",
doi = "10.1086/595847",
language = "English",
volume = "48",
pages = "302--312",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts

AU - Bakir, M

AU - Dosanjh, Davinder

AU - Deeks, Jonathan

AU - Soysal, A

AU - Millington, KA

AU - Efe, S

AU - Aslan, Y

AU - Polat, D

AU - Kodalli, N

AU - Yagci, A

AU - Barlan, I

AU - Bahceciler, N

AU - Demiralp, EE

AU - Lalvani, A

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Background. Treatment of recent tuberculosis infection in children aged ! 2 years is essential, because of high risk of progression to disease, but diagnosis is hindered by the inaccuracy of the tuberculin skin test (TST). More-accurate T cell-based tests of infection could enhance diagnosis by optimizing interpretation of the TST results. Methods. A total of 979 child tuberculosis contacts in Istanbul underwent the TST and enzyme-linked immunospot assay. Using enzyme-linked immunospot test results as a reference standard, we assessed the effect of age and bacille Calmette-Guerin ( BCG) vaccination on the sensitivity and specificity of the TST, and we computed the optimal TST cutoff points, using receiver operating characteristic curves. Results. With a TST cutoff point of >= 10 mm, the sensitivity of the TST was 66% for children aged = 2 years, and overall accuracy was low for children with 1 BCG scar. Conclusions. Negative results of the TST cannot exclude tuberculosis infection for child tuberculosis contacts aged = 2 years, the accuracy of the TST can be improved by adjustment of cutoff points for BCG-vaccinated children but remains poor for children with >1 BCG scar. This methodology can define optimal TST cutoff points for diagnosis of tuberculosis infection tailored to target populations.

AB - Background. Treatment of recent tuberculosis infection in children aged ! 2 years is essential, because of high risk of progression to disease, but diagnosis is hindered by the inaccuracy of the tuberculin skin test (TST). More-accurate T cell-based tests of infection could enhance diagnosis by optimizing interpretation of the TST results. Methods. A total of 979 child tuberculosis contacts in Istanbul underwent the TST and enzyme-linked immunospot assay. Using enzyme-linked immunospot test results as a reference standard, we assessed the effect of age and bacille Calmette-Guerin ( BCG) vaccination on the sensitivity and specificity of the TST, and we computed the optimal TST cutoff points, using receiver operating characteristic curves. Results. With a TST cutoff point of >= 10 mm, the sensitivity of the TST was 66% for children aged = 2 years, and overall accuracy was low for children with 1 BCG scar. Conclusions. Negative results of the TST cannot exclude tuberculosis infection for child tuberculosis contacts aged = 2 years, the accuracy of the TST can be improved by adjustment of cutoff points for BCG-vaccinated children but remains poor for children with >1 BCG scar. This methodology can define optimal TST cutoff points for diagnosis of tuberculosis infection tailored to target populations.

U2 - 10.1086/595847

DO - 10.1086/595847

M3 - Article

C2 - 19123864

VL - 48

SP - 302

EP - 312

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 3

ER -