Urinary L-lactate excretion is increased in renal Fanconi syndrome

Research output: Contribution to journalArticle

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Urinary L-lactate excretion is increased in renal Fanconi syndrome. / Thirumuragan, A; Thewles, Andrew; Gilbert, RD; Hulton, Sally-Anne; Milford, David; Lote, Christopher; Taylor, Christopher.

In: Nephrology, Dialysis, Transplantation, Vol. 19, 01.01.2004, p. 1767-1773.

Research output: Contribution to journalArticle

Harvard

Thirumuragan, A, Thewles, A, Gilbert, RD, Hulton, S-A, Milford, D, Lote, C & Taylor, C 2004, 'Urinary L-lactate excretion is increased in renal Fanconi syndrome', Nephrology, Dialysis, Transplantation, vol. 19, pp. 1767-1773. https://doi.org/10.1093/ndt/gfh213

APA

Thirumuragan, A., Thewles, A., Gilbert, RD., Hulton, S-A., Milford, D., Lote, C., & Taylor, C. (2004). Urinary L-lactate excretion is increased in renal Fanconi syndrome. Nephrology, Dialysis, Transplantation, 19, 1767-1773. https://doi.org/10.1093/ndt/gfh213

Vancouver

Thirumuragan A, Thewles A, Gilbert RD, Hulton S-A, Milford D, Lote C et al. Urinary L-lactate excretion is increased in renal Fanconi syndrome. Nephrology, Dialysis, Transplantation. 2004 Jan 1;19:1767-1773. https://doi.org/10.1093/ndt/gfh213

Author

Thirumuragan, A ; Thewles, Andrew ; Gilbert, RD ; Hulton, Sally-Anne ; Milford, David ; Lote, Christopher ; Taylor, Christopher. / Urinary L-lactate excretion is increased in renal Fanconi syndrome. In: Nephrology, Dialysis, Transplantation. 2004 ; Vol. 19. pp. 1767-1773.

Bibtex

@article{41a14a92d46041c0a4832f7847ef4553,
title = "Urinary L-lactate excretion is increased in renal Fanconi syndrome",
abstract = "Background. Measurement Of L-lactate in body fluids is an established clinical tool to identify disorders of cellular respiration. However, there is very little known about the clinical value of urinary lactate measurements. We investigated urinary lactate excretion in children with renal Fanconi syndrome. Methods. Freshly voided urine samples were obtained from children with Fanconi syndrome and controls both with and without renal disease. Urine lactate was estimated by conversion to pyruvate in the presence of lactate dehydrogenase and NAD. The NADH produced was measured photometrically. Urine lactate was factored for urine creatinine. Results. Children with Fanconi syndrome had a significantly higher urine lactate/creatinine ratio [mean: 84 x 10(-2) mmol/mmol; 95% confidence interval (CI): 40.8-127.1 x 10(-2) mmol/mmol] than healthy controls (mean: 1.3 x 10(-2) mmol/mmol; CI: 1.1- 1.5 x 10(-2) mmol/mmol) and those with a variety of renal diseases (mean: 3.1 x 10(-2) mmol/mmol; CI: 1.8-4.5 x 10(-2) mmol/mmol). Conclusions. Urinary lactate is increased in Fanconi syndrome. The increase is likely to be due to reduced lactate co-transport in the proximal tubule. Urinary lactate/creatinine has clinical utility as a sensitive test of disordered proximal renal tubular function.",
keywords = "lactate co-transport, Fanconi syndrome, urinary lactate cystinosis, proximal tubule disorders",
author = "A Thirumuragan and Andrew Thewles and RD Gilbert and Sally-Anne Hulton and David Milford and Christopher Lote and Christopher Taylor",
year = "2004",
month = jan,
day = "1",
doi = "10.1093/ndt/gfh213",
language = "English",
volume = "19",
pages = "1767--1773",
journal = "Nephrology, Dialysis, Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Urinary L-lactate excretion is increased in renal Fanconi syndrome

AU - Thirumuragan, A

AU - Thewles, Andrew

AU - Gilbert, RD

AU - Hulton, Sally-Anne

AU - Milford, David

AU - Lote, Christopher

AU - Taylor, Christopher

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background. Measurement Of L-lactate in body fluids is an established clinical tool to identify disorders of cellular respiration. However, there is very little known about the clinical value of urinary lactate measurements. We investigated urinary lactate excretion in children with renal Fanconi syndrome. Methods. Freshly voided urine samples were obtained from children with Fanconi syndrome and controls both with and without renal disease. Urine lactate was estimated by conversion to pyruvate in the presence of lactate dehydrogenase and NAD. The NADH produced was measured photometrically. Urine lactate was factored for urine creatinine. Results. Children with Fanconi syndrome had a significantly higher urine lactate/creatinine ratio [mean: 84 x 10(-2) mmol/mmol; 95% confidence interval (CI): 40.8-127.1 x 10(-2) mmol/mmol] than healthy controls (mean: 1.3 x 10(-2) mmol/mmol; CI: 1.1- 1.5 x 10(-2) mmol/mmol) and those with a variety of renal diseases (mean: 3.1 x 10(-2) mmol/mmol; CI: 1.8-4.5 x 10(-2) mmol/mmol). Conclusions. Urinary lactate is increased in Fanconi syndrome. The increase is likely to be due to reduced lactate co-transport in the proximal tubule. Urinary lactate/creatinine has clinical utility as a sensitive test of disordered proximal renal tubular function.

AB - Background. Measurement Of L-lactate in body fluids is an established clinical tool to identify disorders of cellular respiration. However, there is very little known about the clinical value of urinary lactate measurements. We investigated urinary lactate excretion in children with renal Fanconi syndrome. Methods. Freshly voided urine samples were obtained from children with Fanconi syndrome and controls both with and without renal disease. Urine lactate was estimated by conversion to pyruvate in the presence of lactate dehydrogenase and NAD. The NADH produced was measured photometrically. Urine lactate was factored for urine creatinine. Results. Children with Fanconi syndrome had a significantly higher urine lactate/creatinine ratio [mean: 84 x 10(-2) mmol/mmol; 95% confidence interval (CI): 40.8-127.1 x 10(-2) mmol/mmol] than healthy controls (mean: 1.3 x 10(-2) mmol/mmol; CI: 1.1- 1.5 x 10(-2) mmol/mmol) and those with a variety of renal diseases (mean: 3.1 x 10(-2) mmol/mmol; CI: 1.8-4.5 x 10(-2) mmol/mmol). Conclusions. Urinary lactate is increased in Fanconi syndrome. The increase is likely to be due to reduced lactate co-transport in the proximal tubule. Urinary lactate/creatinine has clinical utility as a sensitive test of disordered proximal renal tubular function.

KW - lactate co-transport

KW - Fanconi syndrome

KW - urinary lactate cystinosis

KW - proximal tubule disorders

UR - http://www.scopus.com/inward/record.url?scp=3242733801&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfh213

DO - 10.1093/ndt/gfh213

M3 - Article

VL - 19

SP - 1767

EP - 1773

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

SN - 0931-0509

ER -