Urinary biomarkers of acute kidney injury in deceased organ donors - kidney injury molecule-1 as an adjunct to predicting outcome

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Urinary biomarkers of acute kidney injury in deceased organ donors - kidney injury molecule-1 as an adjunct to predicting outcome. / Field, Melanie; Dronavalli, Vamsi; Mistry, Punam; Drayson, Mark; Ready, Andrew; Cobbold, Mark; Inston, Nicholas.

In: Clinical transplantation, Vol. 28, No. 7, 01.07.2014, p. 808-815.

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Field, Melanie ; Dronavalli, Vamsi ; Mistry, Punam ; Drayson, Mark ; Ready, Andrew ; Cobbold, Mark ; Inston, Nicholas. / Urinary biomarkers of acute kidney injury in deceased organ donors - kidney injury molecule-1 as an adjunct to predicting outcome. In: Clinical transplantation. 2014 ; Vol. 28, No. 7. pp. 808-815.

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@article{506bd54ef3c84f7989ef76602d5d4f25,
title = "Urinary biomarkers of acute kidney injury in deceased organ donors - kidney injury molecule-1 as an adjunct to predicting outcome",
abstract = "BackgroundDeceased kidney donors are increasingly “marginal,” and many have risk factors for acute kidney injury (AKI) that may impact on subsequent renal transplant outcome. Despite this, determining the presence of AKI at the time of deceased organ donation remains difficult.MethodsUrine samples from 182 brainstem dead multi-organ donors (all of whom donated hearts that were transplanted) were analyzed for a Luminex{\texttrademark} panel of biomarkers linked with AKI. This included KIM-1, NGAL, IFN-γ, TNF-α, cystatin C, Fractalkine and vascular endothelial growth factor. Levels were correlated to early renal transplant outcomes, most specifically delayed graft function.ResultsDonor urinary KIM-1 levels were significantly higher in donors whose kidneys displayed aberrant early function (p = 0.011). Fractalkine levels showed a trend toward elevation in such donors but uncorrected this did not attain significance. No correlation occurred with the remaining biomarkers.ConclusionsKIM-1 appears to show promise as a marker for AKI in deceased cardiac organ donors. The availability of a lateral flow device (Renastick{\texttrademark}) for KIM-1 that also demonstrates higher urinary KIM-1 levels in donors whose kidneys show aberrant initial function (p = 0.03), makes KIM-1 a potential indicator of AKI that may merit further evaluation for its application at the donor bedside.",
author = "Melanie Field and Vamsi Dronavalli and Punam Mistry and Mark Drayson and Andrew Ready and Mark Cobbold and Nicholas Inston",
year = "2014",
month = jul,
day = "1",
doi = "10.1111/ctr.2014.28.issue-7",
language = "English",
volume = "28",
pages = "808--815",
journal = "Clinical transplantation",
issn = "0902-0063",
publisher = "Wiley",
number = "7",

}

RIS

TY - JOUR

T1 - Urinary biomarkers of acute kidney injury in deceased organ donors - kidney injury molecule-1 as an adjunct to predicting outcome

AU - Field, Melanie

AU - Dronavalli, Vamsi

AU - Mistry, Punam

AU - Drayson, Mark

AU - Ready, Andrew

AU - Cobbold, Mark

AU - Inston, Nicholas

PY - 2014/7/1

Y1 - 2014/7/1

N2 - BackgroundDeceased kidney donors are increasingly “marginal,” and many have risk factors for acute kidney injury (AKI) that may impact on subsequent renal transplant outcome. Despite this, determining the presence of AKI at the time of deceased organ donation remains difficult.MethodsUrine samples from 182 brainstem dead multi-organ donors (all of whom donated hearts that were transplanted) were analyzed for a Luminex™ panel of biomarkers linked with AKI. This included KIM-1, NGAL, IFN-γ, TNF-α, cystatin C, Fractalkine and vascular endothelial growth factor. Levels were correlated to early renal transplant outcomes, most specifically delayed graft function.ResultsDonor urinary KIM-1 levels were significantly higher in donors whose kidneys displayed aberrant early function (p = 0.011). Fractalkine levels showed a trend toward elevation in such donors but uncorrected this did not attain significance. No correlation occurred with the remaining biomarkers.ConclusionsKIM-1 appears to show promise as a marker for AKI in deceased cardiac organ donors. The availability of a lateral flow device (Renastick™) for KIM-1 that also demonstrates higher urinary KIM-1 levels in donors whose kidneys show aberrant initial function (p = 0.03), makes KIM-1 a potential indicator of AKI that may merit further evaluation for its application at the donor bedside.

AB - BackgroundDeceased kidney donors are increasingly “marginal,” and many have risk factors for acute kidney injury (AKI) that may impact on subsequent renal transplant outcome. Despite this, determining the presence of AKI at the time of deceased organ donation remains difficult.MethodsUrine samples from 182 brainstem dead multi-organ donors (all of whom donated hearts that were transplanted) were analyzed for a Luminex™ panel of biomarkers linked with AKI. This included KIM-1, NGAL, IFN-γ, TNF-α, cystatin C, Fractalkine and vascular endothelial growth factor. Levels were correlated to early renal transplant outcomes, most specifically delayed graft function.ResultsDonor urinary KIM-1 levels were significantly higher in donors whose kidneys displayed aberrant early function (p = 0.011). Fractalkine levels showed a trend toward elevation in such donors but uncorrected this did not attain significance. No correlation occurred with the remaining biomarkers.ConclusionsKIM-1 appears to show promise as a marker for AKI in deceased cardiac organ donors. The availability of a lateral flow device (Renastick™) for KIM-1 that also demonstrates higher urinary KIM-1 levels in donors whose kidneys show aberrant initial function (p = 0.03), makes KIM-1 a potential indicator of AKI that may merit further evaluation for its application at the donor bedside.

U2 - 10.1111/ctr.2014.28.issue-7

DO - 10.1111/ctr.2014.28.issue-7

M3 - Article

VL - 28

SP - 808

EP - 815

JO - Clinical transplantation

JF - Clinical transplantation

SN - 0902-0063

IS - 7

ER -