Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll station workers in Taipai, Taiwan

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Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll station workers in Taipai, Taiwan. / Lai, CH; Liou, SH; Shih, TS; Tsai, PY; Chen, HL; Buckley, T; Strickland, P; Jaakkola, Jouni.

In: Arch Environ Health, Vol. 59, 01.02.2004, p. 61-69.

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@article{84f7d3aa7ff146e58bb96db860494835,
title = "Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll station workers in Taipai, Taiwan",
abstract = "In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 mu mol/mol creatinine in the exposed group and 0.073 mu mol/mol creatinine in the reference group (difference in mean concentrations: 0.044 mu mol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 mu mol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 mu mol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.",
author = "CH Lai and SH Liou and TS Shih and PY Tsai and HL Chen and T Buckley and P Strickland and Jouni Jaakkola",
year = "2004",
month = feb,
day = "1",
doi = "10.3200/AEOH.59.2.61-69",
language = "English",
volume = "59",
pages = "61--69",
journal = "Arch Environ Health",
issn = "0003-9896",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll station workers in Taipai, Taiwan

AU - Lai, CH

AU - Liou, SH

AU - Shih, TS

AU - Tsai, PY

AU - Chen, HL

AU - Buckley, T

AU - Strickland, P

AU - Jaakkola, Jouni

PY - 2004/2/1

Y1 - 2004/2/1

N2 - In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 mu mol/mol creatinine in the exposed group and 0.073 mu mol/mol creatinine in the reference group (difference in mean concentrations: 0.044 mu mol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 mu mol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 mu mol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.

AB - In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 mu mol/mol creatinine in the exposed group and 0.073 mu mol/mol creatinine in the reference group (difference in mean concentrations: 0.044 mu mol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 mu mol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 mu mol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.

UR - http://www.scopus.com/inward/record.url?scp=23044446493&partnerID=8YFLogxK

U2 - 10.3200/AEOH.59.2.61-69

DO - 10.3200/AEOH.59.2.61-69

M3 - Article

C2 - 16075899

VL - 59

SP - 61

EP - 69

JO - Arch Environ Health

JF - Arch Environ Health

SN - 0003-9896

ER -