TY - JOUR
T1 - Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll station workers in Taipai, Taiwan
AU - Lai, CH
AU - Liou, SH
AU - Shih, TS
AU - Tsai, PY
AU - Chen, HL
AU - Buckley, T
AU - Strickland, P
AU - Jaakkola, Jouni
PY - 2004/2/1
Y1 - 2004/2/1
N2 - In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 mu mol/mol creatinine in the exposed group and 0.073 mu mol/mol creatinine in the reference group (difference in mean concentrations: 0.044 mu mol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 mu mol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 mu mol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.
AB - In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 mu mol/mol creatinine in the exposed group and 0.073 mu mol/mol creatinine in the reference group (difference in mean concentrations: 0.044 mu mol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 mu mol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 mu mol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.
UR - http://www.scopus.com/inward/record.url?scp=23044446493&partnerID=8YFLogxK
U2 - 10.3200/AEOH.59.2.61-69
DO - 10.3200/AEOH.59.2.61-69
M3 - Article
C2 - 16075899
VL - 59
SP - 61
EP - 69
JO - Arch Environ Health
JF - Arch Environ Health
ER -