Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

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Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. / Beilina, Alexandria; Rudenko, Iakov N; Kaganovich, Alice; Civiero, Laura; Chau, Hien; Kalia, Suneil K; Kalia, Lorraine V; Lobbestael, Evy; Chia, Ruth; Ndukwe, Kelechi; Ding, Jinhui; Nalls, Mike A; Olszewski, Maciej; Hauser, David N; Kumaran, Ravindran; Lozano, Andres M; Baekelandt, Veerle; Greene, Lois E; Taymans, Jean-Marc; Greggio, Elisa; Cookson, Mark R; International Parkinson's Disease Genomics Consortium (IPDGC) ; Morrison, Karen.

In: National Academy of Sciences. Proceedings, Vol. 111, No. 7, 18.02.2014, p. 2626-31.

Research output: Contribution to journalArticle

Harvard

Beilina, A, Rudenko, IN, Kaganovich, A, Civiero, L, Chau, H, Kalia, SK, Kalia, LV, Lobbestael, E, Chia, R, Ndukwe, K, Ding, J, Nalls, MA, Olszewski, M, Hauser, DN, Kumaran, R, Lozano, AM, Baekelandt, V, Greene, LE, Taymans, J-M, Greggio, E, Cookson, MR, International Parkinson's Disease Genomics Consortium (IPDGC) & Morrison, K 2014, 'Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease', National Academy of Sciences. Proceedings, vol. 111, no. 7, pp. 2626-31. https://doi.org/10.1073/pnas.1318306111

APA

Beilina, A., Rudenko, I. N., Kaganovich, A., Civiero, L., Chau, H., Kalia, S. K., Kalia, L. V., Lobbestael, E., Chia, R., Ndukwe, K., Ding, J., Nalls, M. A., Olszewski, M., Hauser, D. N., Kumaran, R., Lozano, A. M., Baekelandt, V., Greene, L. E., Taymans, J-M., ... Morrison, K. (2014). Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. National Academy of Sciences. Proceedings, 111(7), 2626-31. https://doi.org/10.1073/pnas.1318306111

Vancouver

Author

Beilina, Alexandria ; Rudenko, Iakov N ; Kaganovich, Alice ; Civiero, Laura ; Chau, Hien ; Kalia, Suneil K ; Kalia, Lorraine V ; Lobbestael, Evy ; Chia, Ruth ; Ndukwe, Kelechi ; Ding, Jinhui ; Nalls, Mike A ; Olszewski, Maciej ; Hauser, David N ; Kumaran, Ravindran ; Lozano, Andres M ; Baekelandt, Veerle ; Greene, Lois E ; Taymans, Jean-Marc ; Greggio, Elisa ; Cookson, Mark R ; International Parkinson's Disease Genomics Consortium (IPDGC) ; Morrison, Karen. / Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. In: National Academy of Sciences. Proceedings. 2014 ; Vol. 111, No. 7. pp. 2626-31.

Bibtex

@article{5bf4d92a03f4406383d2a2db8770ffad,
title = "Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease",
abstract = "Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies. These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system both in vitro and in vivo. We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms.",
keywords = "Adaptor Proteins, Signal Transducing, Analysis of Variance, Blotting, Western, Brain, Cell Fractionation, DNA Primers, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Golgi Apparatus, HEK293 Cells, Humans, Immunoprecipitation, Intracellular Signaling Peptides and Proteins, Mass Spectrometry, Microscopy, Confocal, Multiprotein Complexes, Parkinson Disease, Plasmids, Protein Interaction Mapping, Protein-Serine-Threonine Kinases, Transport Vesicles, rab GTP-Binding Proteins",
author = "Alexandria Beilina and Rudenko, {Iakov N} and Alice Kaganovich and Laura Civiero and Hien Chau and Kalia, {Suneil K} and Kalia, {Lorraine V} and Evy Lobbestael and Ruth Chia and Kelechi Ndukwe and Jinhui Ding and Nalls, {Mike A} and Maciej Olszewski and Hauser, {David N} and Ravindran Kumaran and Lozano, {Andres M} and Veerle Baekelandt and Greene, {Lois E} and Jean-Marc Taymans and Elisa Greggio and Cookson, {Mark R} and {International Parkinson's Disease Genomics Consortium (IPDGC)} and Karen Morrison",
year = "2014",
month = feb,
day = "18",
doi = "10.1073/pnas.1318306111",
language = "English",
volume = "111",
pages = "2626--31",
journal = "National Academy of Sciences. Proceedings",
issn = "1091-6490",
publisher = "National Academy of Sciences",
number = "7",

}

RIS

TY - JOUR

T1 - Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

AU - Beilina, Alexandria

AU - Rudenko, Iakov N

AU - Kaganovich, Alice

AU - Civiero, Laura

AU - Chau, Hien

AU - Kalia, Suneil K

AU - Kalia, Lorraine V

AU - Lobbestael, Evy

AU - Chia, Ruth

AU - Ndukwe, Kelechi

AU - Ding, Jinhui

AU - Nalls, Mike A

AU - Olszewski, Maciej

AU - Hauser, David N

AU - Kumaran, Ravindran

AU - Lozano, Andres M

AU - Baekelandt, Veerle

AU - Greene, Lois E

AU - Taymans, Jean-Marc

AU - Greggio, Elisa

AU - Cookson, Mark R

AU - International Parkinson's Disease Genomics Consortium (IPDGC)

AU - Morrison, Karen

PY - 2014/2/18

Y1 - 2014/2/18

N2 - Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies. These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system both in vitro and in vivo. We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms.

AB - Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein-protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G-associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies. These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy-lysosome system both in vitro and in vivo. We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms.

KW - Adaptor Proteins, Signal Transducing

KW - Analysis of Variance

KW - Blotting, Western

KW - Brain

KW - Cell Fractionation

KW - DNA Primers

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Golgi Apparatus

KW - HEK293 Cells

KW - Humans

KW - Immunoprecipitation

KW - Intracellular Signaling Peptides and Proteins

KW - Mass Spectrometry

KW - Microscopy, Confocal

KW - Multiprotein Complexes

KW - Parkinson Disease

KW - Plasmids

KW - Protein Interaction Mapping

KW - Protein-Serine-Threonine Kinases

KW - Transport Vesicles

KW - rab GTP-Binding Proteins

U2 - 10.1073/pnas.1318306111

DO - 10.1073/pnas.1318306111

M3 - Article

C2 - 24510904

VL - 111

SP - 2626

EP - 2631

JO - National Academy of Sciences. Proceedings

JF - National Academy of Sciences. Proceedings

SN - 1091-6490

IS - 7

ER -