Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall

Research output: Contribution to journalArticlepeer-review

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Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall. / Stewart , Fraser; Cummins, Gerard; Turcanu , Mihnea; Cox, Benjamin; Prescott, Alan ; Clutton, Eddie ; Newton, Ian; Desmulliez, Marc; Thanou, Maya; Mulvana, Helen; Cochran, Sandy ; Nathke, Inke.

In: Scientific Reports, Vol. 11, No. 1, 2584, 12.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Stewart , F, Cummins, G, Turcanu , M, Cox, B, Prescott, A, Clutton, E, Newton, I, Desmulliez, M, Thanou, M, Mulvana, H, Cochran, S & Nathke, I 2021, 'Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall', Scientific Reports, vol. 11, no. 1, 2584. https://doi.org/10.1038/s41598-021-82240-1

APA

Stewart , F., Cummins, G., Turcanu , M., Cox, B., Prescott, A., Clutton, E., Newton, I., Desmulliez, M., Thanou, M., Mulvana, H., Cochran, S., & Nathke, I. (2021). Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall. Scientific Reports, 11(1), [2584]. https://doi.org/10.1038/s41598-021-82240-1

Vancouver

Author

Stewart , Fraser ; Cummins, Gerard ; Turcanu , Mihnea ; Cox, Benjamin ; Prescott, Alan ; Clutton, Eddie ; Newton, Ian ; Desmulliez, Marc ; Thanou, Maya ; Mulvana, Helen ; Cochran, Sandy ; Nathke, Inke. / Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

Bibtex

@article{7b109f86672f467d83b870d27a76afba,
title = "Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall",
abstract = "Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections because of their poor bioavailability via oral routes. Delivery of biologics to the small intestine using electronic delivery with devices that are similar to capsule endoscopes is a promising means of overcoming this limitation and does not require reformulation of the therapeutic agent. The efficacy of such capsule devices for drug delivery could be further improved by increasing the permeability of the intestinal tract lining with an integrated ultrasound transducer to increase uptake. This paper describes a novel proof of concept capsule device capable of electronic application of focused ultrasound and delivery of therapeutic agents. Fluorescent markers, which were chosen as a model drug, were used to demonstrate in vivo delivery in the porcine small intestine with this capsule. We show that the fluorescent markers can penetrate the mucus layer of the small intestine at low acoustic powers when combining microbubbles with focused ultrasound during in vivo experiments using porcine models. This study illustrates how such a device could be potentially used for gastrointestinal drug delivery and the challenges to be overcome before focused ultrasound and microbubbles could be used with this device for the oral delivery of biologic therapeutics.",
author = "Fraser Stewart and Gerard Cummins and Mihnea Turcanu and Benjamin Cox and Alan Prescott and Eddie Clutton and Ian Newton and Marc Desmulliez and Maya Thanou and Helen Mulvana and Sandy Cochran and Inke Nathke",
note = "Funding Information: Financial support is gratefully acknowledged from the UK Engineering and Physical Sciences Research Council (EPSRC), Grant EP/K034537 (Sonopill Programme), and the Biotechnology and Biological Sciences Research Council (BBSRC), Grant BB/M017079/1. Microscope access was provided by the Dundee Imaging Facility; the Zeiss LSM 880 Airyscan microscope was funded by an MRC Grant to the Protein Phosphorylation and Ubiq-uitylation Unit. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = jan,
day = "28",
doi = "10.1038/s41598-021-82240-1",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall

AU - Stewart , Fraser

AU - Cummins, Gerard

AU - Turcanu , Mihnea

AU - Cox, Benjamin

AU - Prescott, Alan

AU - Clutton, Eddie

AU - Newton, Ian

AU - Desmulliez, Marc

AU - Thanou, Maya

AU - Mulvana, Helen

AU - Cochran, Sandy

AU - Nathke, Inke

N1 - Funding Information: Financial support is gratefully acknowledged from the UK Engineering and Physical Sciences Research Council (EPSRC), Grant EP/K034537 (Sonopill Programme), and the Biotechnology and Biological Sciences Research Council (BBSRC), Grant BB/M017079/1. Microscope access was provided by the Dundee Imaging Facility; the Zeiss LSM 880 Airyscan microscope was funded by an MRC Grant to the Protein Phosphorylation and Ubiq-uitylation Unit. Publisher Copyright: © 2021, The Author(s).

PY - 2021/1/28

Y1 - 2021/1/28

N2 - Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections because of their poor bioavailability via oral routes. Delivery of biologics to the small intestine using electronic delivery with devices that are similar to capsule endoscopes is a promising means of overcoming this limitation and does not require reformulation of the therapeutic agent. The efficacy of such capsule devices for drug delivery could be further improved by increasing the permeability of the intestinal tract lining with an integrated ultrasound transducer to increase uptake. This paper describes a novel proof of concept capsule device capable of electronic application of focused ultrasound and delivery of therapeutic agents. Fluorescent markers, which were chosen as a model drug, were used to demonstrate in vivo delivery in the porcine small intestine with this capsule. We show that the fluorescent markers can penetrate the mucus layer of the small intestine at low acoustic powers when combining microbubbles with focused ultrasound during in vivo experiments using porcine models. This study illustrates how such a device could be potentially used for gastrointestinal drug delivery and the challenges to be overcome before focused ultrasound and microbubbles could be used with this device for the oral delivery of biologic therapeutics.

AB - Biologic drugs, defined as therapeutic agents produced from or containing components of a living organism, are of growing importance to the pharmaceutical industry. Though oral delivery of medicine is convenient, biologics require invasive injections because of their poor bioavailability via oral routes. Delivery of biologics to the small intestine using electronic delivery with devices that are similar to capsule endoscopes is a promising means of overcoming this limitation and does not require reformulation of the therapeutic agent. The efficacy of such capsule devices for drug delivery could be further improved by increasing the permeability of the intestinal tract lining with an integrated ultrasound transducer to increase uptake. This paper describes a novel proof of concept capsule device capable of electronic application of focused ultrasound and delivery of therapeutic agents. Fluorescent markers, which were chosen as a model drug, were used to demonstrate in vivo delivery in the porcine small intestine with this capsule. We show that the fluorescent markers can penetrate the mucus layer of the small intestine at low acoustic powers when combining microbubbles with focused ultrasound during in vivo experiments using porcine models. This study illustrates how such a device could be potentially used for gastrointestinal drug delivery and the challenges to be overcome before focused ultrasound and microbubbles could be used with this device for the oral delivery of biologic therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=85100048442&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-82240-1

DO - 10.1038/s41598-021-82240-1

M3 - Article

C2 - 33510366

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 2584

ER -