Abstract
BACKGROUND: The nonstructural 3 serine protease inhibitors (PIs), boceprevir and telaprevir, represent the first in a new generation of directly acting antivirals against genotype 1 hepatitis C (HCV) infection. When used in combination with pegylated interferon and ribavirin, these drugs greatly improve sustained virological response rates in both treatment-naïve patients and patients who have had previous virological failure on treatment. However, the addition of these new agents will increase the complexity of therapeutic regimens, the rates of side-effects and costs.
AIMS: To review concisely the current evidence and to suggest current best practice, for the use of telaprevir and boceprevir in the management of chronic genotype 1 HCV infection.
METHODS: These guidelines for the use of boceprevir and telaprevir have been formulated following extensive review of the current literature, are based on the consensus opinion of a panel of national experts, and have been openly discussed and debated at a national meeting of HCV care providers.
RESULTS: We have made recommendations on a number of the key practical issues facing HCV care providers: (i) Which patients to treat?; (ii) Standards for the provision of care; (iii) Pre-treatment considerations; (iv) Which treatment regimens to use?; (v) Stopping rules; and (vi) Management of adverse effects. Finally, we have produced suggested algorithms for the assessment and treatment of these patients.
CONCLUSIONS: These UK Consensus guidelines indicate the current best practice for the use of boceprevir and telaprevir in the management of genotype 1 chronic HCV infection.
Original language | English |
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Pages (from-to) | 647-62 |
Number of pages | 16 |
Journal | Alimentary Pharmacology & Therapeutics |
Volume | 35 |
Issue number | 6 |
DOIs | |
Publication status | Published - Mar 2012 |
Keywords
- Algorithms
- Antiviral Agents
- Drug Therapy, Combination
- Genotype
- Great Britain
- Hepacivirus
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Oligopeptides
- Patient Selection
- Polyethylene Glycols
- Proline
- Randomized Controlled Trials as Topic
- Recombinant Proteins
- Ribavirin
- Serine Proteinase Inhibitors
- Viral Load