Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses

Research output: Contribution to journalArticle

Standard

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. / Teles, Rosane M B; Graeber, Thomas G; Krutzik, Stephan R; Montoya, Dennis; Schenk, Mirjam; Lee, Delphine J; Komisopoulou, Evangelia; Kelly-Scumpia, Kindra; Chun, Rene; Iyer, Shankar S; Sarno, Euzenir N; Rea, Thomas H; Hewison, Martin; Adams, John S; Popper, Stephen J; Relman, David A; Stenger, Steffen; Bloom, Barry R; Cheng, Genhong; Modlin, Robert L.

In: Science, Vol. 339, No. 6126, 22.03.2013, p. 1448-53.

Research output: Contribution to journalArticle

Harvard

Teles, RMB, Graeber, TG, Krutzik, SR, Montoya, D, Schenk, M, Lee, DJ, Komisopoulou, E, Kelly-Scumpia, K, Chun, R, Iyer, SS, Sarno, EN, Rea, TH, Hewison, M, Adams, JS, Popper, SJ, Relman, DA, Stenger, S, Bloom, BR, Cheng, G & Modlin, RL 2013, 'Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses', Science, vol. 339, no. 6126, pp. 1448-53. https://doi.org/10.1126/science.1233665

APA

Teles, R. M. B., Graeber, T. G., Krutzik, S. R., Montoya, D., Schenk, M., Lee, D. J., Komisopoulou, E., Kelly-Scumpia, K., Chun, R., Iyer, S. S., Sarno, E. N., Rea, T. H., Hewison, M., Adams, J. S., Popper, S. J., Relman, D. A., Stenger, S., Bloom, B. R., Cheng, G., & Modlin, R. L. (2013). Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science, 339(6126), 1448-53. https://doi.org/10.1126/science.1233665

Vancouver

Teles RMB, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ et al. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science. 2013 Mar 22;339(6126):1448-53. https://doi.org/10.1126/science.1233665

Author

Teles, Rosane M B ; Graeber, Thomas G ; Krutzik, Stephan R ; Montoya, Dennis ; Schenk, Mirjam ; Lee, Delphine J ; Komisopoulou, Evangelia ; Kelly-Scumpia, Kindra ; Chun, Rene ; Iyer, Shankar S ; Sarno, Euzenir N ; Rea, Thomas H ; Hewison, Martin ; Adams, John S ; Popper, Stephen J ; Relman, David A ; Stenger, Steffen ; Bloom, Barry R ; Cheng, Genhong ; Modlin, Robert L. / Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. In: Science. 2013 ; Vol. 339, No. 6126. pp. 1448-53.

Bibtex

@article{47d46acb5772445baddf25ac44e9700c,
title = "Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses",
abstract = "Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-β and IFN-γ gene expression programs. IFN-γ and its downstream vitamin D-dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against the pathogen Mycobacterium leprae in vitro. In contrast, IFN-β and its downstream genes, including interleukin-10 (IL-10), were induced in monocytes by M. leprae in vitro and preferentially expressed in disseminated and progressive lepromatous lesions. The IFN-γ-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-β and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.",
keywords = "25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Antimicrobial Cationic Peptides, Humans, Interferon-beta, Interferon-gamma, Interleukin-10, Leprosy, Lepromatous, Leprosy, Tuberculoid, Microbial Viability, Monocytes, Mycobacterium leprae, RNA, Messenger, Receptors, Calcitriol, Transcriptome, Tuberculosis, Up-Regulation, beta-Defensins",
author = "Teles, {Rosane M B} and Graeber, {Thomas G} and Krutzik, {Stephan R} and Dennis Montoya and Mirjam Schenk and Lee, {Delphine J} and Evangelia Komisopoulou and Kindra Kelly-Scumpia and Rene Chun and Iyer, {Shankar S} and Sarno, {Euzenir N} and Rea, {Thomas H} and Martin Hewison and Adams, {John S} and Popper, {Stephen J} and Relman, {David A} and Steffen Stenger and Bloom, {Barry R} and Genhong Cheng and Modlin, {Robert L}",
year = "2013",
month = mar,
day = "22",
doi = "10.1126/science.1233665",
language = "English",
volume = "339",
pages = "1448--53",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6126",

}

RIS

TY - JOUR

T1 - Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses

AU - Teles, Rosane M B

AU - Graeber, Thomas G

AU - Krutzik, Stephan R

AU - Montoya, Dennis

AU - Schenk, Mirjam

AU - Lee, Delphine J

AU - Komisopoulou, Evangelia

AU - Kelly-Scumpia, Kindra

AU - Chun, Rene

AU - Iyer, Shankar S

AU - Sarno, Euzenir N

AU - Rea, Thomas H

AU - Hewison, Martin

AU - Adams, John S

AU - Popper, Stephen J

AU - Relman, David A

AU - Stenger, Steffen

AU - Bloom, Barry R

AU - Cheng, Genhong

AU - Modlin, Robert L

PY - 2013/3/22

Y1 - 2013/3/22

N2 - Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-β and IFN-γ gene expression programs. IFN-γ and its downstream vitamin D-dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against the pathogen Mycobacterium leprae in vitro. In contrast, IFN-β and its downstream genes, including interleukin-10 (IL-10), were induced in monocytes by M. leprae in vitro and preferentially expressed in disseminated and progressive lepromatous lesions. The IFN-γ-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-β and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.

AB - Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-β and IFN-γ gene expression programs. IFN-γ and its downstream vitamin D-dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against the pathogen Mycobacterium leprae in vitro. In contrast, IFN-β and its downstream genes, including interleukin-10 (IL-10), were induced in monocytes by M. leprae in vitro and preferentially expressed in disseminated and progressive lepromatous lesions. The IFN-γ-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-β and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.

KW - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

KW - Antimicrobial Cationic Peptides

KW - Humans

KW - Interferon-beta

KW - Interferon-gamma

KW - Interleukin-10

KW - Leprosy, Lepromatous

KW - Leprosy, Tuberculoid

KW - Microbial Viability

KW - Monocytes

KW - Mycobacterium leprae

KW - RNA, Messenger

KW - Receptors, Calcitriol

KW - Transcriptome

KW - Tuberculosis

KW - Up-Regulation

KW - beta-Defensins

U2 - 10.1126/science.1233665

DO - 10.1126/science.1233665

M3 - Article

C2 - 23449998

VL - 339

SP - 1448

EP - 1453

JO - Science

JF - Science

SN - 0036-8075

IS - 6126

ER -