Abstract
IUF1 is a pancreatic β cell-specific factor which binds to the sequence 5′-CPyCTAATG-3′ (CT box) within the human insulin gene enhancer. Here we show that IUF1 is composed of 2 binding activities that can be separated by DEAE ion exchange chromatography. South Western blot analysis indicates that these distinct binding activities have apparent molecular weights of 115 kDa and 46 kDa.
Original language | English |
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Pages (from-to) | 27-30 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 290 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 23 Sept 1991 |
Bibliographical note
Funding Information:Ackrro,c’l~~lgTtmhise rwõrtk: was supportedby a grant from the WellcomeT rust.
Keywords
- Gene expression
- Insulin gene
- Transcription factor
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology