Tumour-suppression function of KLF12 through regulation of anoikis

N Godin-Heymann; S Brabetz; M M Murillo; M Saponaro; C R Santos; A Lobley; P East; P Chakravarty; N Matthews; G Kelly; S Jordan; E Castellano; J Downward

doi:10.1038/onc.2015.394

Tumour-suppression function of KLF12 through regulation of anoikis

N Godin-Heymann, S Brabetz, M M Murillo, M Saponaro, C R Santos, A Lobley, P East, P Chakravarty, N Matthews, G Kelly, S Jordan, E Castellano, J Downward

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Abstract

Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.Oncogene advance online publication, 12 October 2015; doi:10.1038/onc.2015.394.

Original language	English
Journal	Oncogene
Early online date	12 Oct 2015
DOIs	https://doi.org/10.1038/onc.2015.394
Publication status	Published - 12 Oct 2015

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title = "Tumour-suppression function of KLF12 through regulation of anoikis",

abstract = "Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.Oncogene advance online publication, 12 October 2015; doi:10.1038/onc.2015.394.",

author = "N Godin-Heymann and S Brabetz and Murillo, {M M} and M Saponaro and Santos, {C R} and A Lobley and P East and P Chakravarty and N Matthews and G Kelly and S Jordan and E Castellano and J Downward",

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AU - Godin-Heymann, N

AU - Brabetz, S

AU - Murillo, M M

AU - Saponaro, M

AU - Santos, C R

AU - Lobley, A

AU - East, P

AU - Chakravarty, P

AU - Matthews, N

AU - Kelly, G

AU - Jordan, S

AU - Castellano, E

AU - Downward, J

PY - 2015/10/12

Y1 - 2015/10/12

N2 - Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.Oncogene advance online publication, 12 October 2015; doi:10.1038/onc.2015.394.

AB - Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.Oncogene advance online publication, 12 October 2015; doi:10.1038/onc.2015.394.

U2 - 10.1038/onc.2015.394

DO - 10.1038/onc.2015.394

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SN - 0950-9232

JO - Oncogene

JF - Oncogene

ER -

Tumour-suppression function of KLF12 through regulation of anoikis

Abstract

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