Tumour necrosis factor-α in Barrett's oesophagus: A potential novel mechanism of action

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Tumour necrosis factor-α in Barrett's oesophagus: A potential novel mechanism of action. / Tselepis, Chris; Perry, Ian; Dawson, Christopher; Hardy, Robert; Darnton, SJ; McConkey, Christopher; Stuart, RC; Wright, N; Harrison, R; Jankowski, Janusz.

In: Oncogene, Vol. 21, No. 39, 05.09.2002, p. 6071-6081.

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@article{5b8f8ede961446b196c2b6e147e02941,
title = "Tumour necrosis factor-α in Barrett's oesophagus: A potential novel mechanism of action",
abstract = "Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM and BA are associated with reduced E-cadherin expression and increased cytoplasmic/nuclear pools of its associated protein beta-catenin. beta-catenin participates in Wnt signalling and activates oncogene transcription by complexing with T-cells factors (TCF). One such oncogene is c-myc. We have previously shown that TNF-alpha can down-regulate E-cadherin expression. Here, we assess TNF-alpha expression in Barrett's metaplasia and examine if TNF-alpha can promote beta-catenin mediated transcription of oncogenes in a gastrointestinal model system. Employing immunohistochemistry and Western blot analysis of oesophageal tissue, epithelial expression of TNF-alpha increases with progression along the metaplasia-dysplasia-carcinoma sequence (P",
keywords = "tumour necrosis factor-alpha (TNF-alpha), cadherins and catenins, cancer, Barrett's oesophagus",
author = "Chris Tselepis and Ian Perry and Christopher Dawson and Robert Hardy and SJ Darnton and Christopher McConkey and RC Stuart and N Wright and R Harrison and Janusz Jankowski",
year = "2002",
month = sep,
day = "5",
doi = "10.1038/sj.onc.1205731",
language = "English",
volume = "21",
pages = "6071--6081",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "39",

}

RIS

TY - JOUR

T1 - Tumour necrosis factor-α in Barrett's oesophagus: A potential novel mechanism of action

AU - Tselepis, Chris

AU - Perry, Ian

AU - Dawson, Christopher

AU - Hardy, Robert

AU - Darnton, SJ

AU - McConkey, Christopher

AU - Stuart, RC

AU - Wright, N

AU - Harrison, R

AU - Jankowski, Janusz

PY - 2002/9/5

Y1 - 2002/9/5

N2 - Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM and BA are associated with reduced E-cadherin expression and increased cytoplasmic/nuclear pools of its associated protein beta-catenin. beta-catenin participates in Wnt signalling and activates oncogene transcription by complexing with T-cells factors (TCF). One such oncogene is c-myc. We have previously shown that TNF-alpha can down-regulate E-cadherin expression. Here, we assess TNF-alpha expression in Barrett's metaplasia and examine if TNF-alpha can promote beta-catenin mediated transcription of oncogenes in a gastrointestinal model system. Employing immunohistochemistry and Western blot analysis of oesophageal tissue, epithelial expression of TNF-alpha increases with progression along the metaplasia-dysplasia-carcinoma sequence (P

AB - Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM and BA are associated with reduced E-cadherin expression and increased cytoplasmic/nuclear pools of its associated protein beta-catenin. beta-catenin participates in Wnt signalling and activates oncogene transcription by complexing with T-cells factors (TCF). One such oncogene is c-myc. We have previously shown that TNF-alpha can down-regulate E-cadherin expression. Here, we assess TNF-alpha expression in Barrett's metaplasia and examine if TNF-alpha can promote beta-catenin mediated transcription of oncogenes in a gastrointestinal model system. Employing immunohistochemistry and Western blot analysis of oesophageal tissue, epithelial expression of TNF-alpha increases with progression along the metaplasia-dysplasia-carcinoma sequence (P

KW - tumour necrosis factor-alpha (TNF-alpha)

KW - cadherins and catenins

KW - cancer

KW - Barrett's oesophagus

UR - http://www.scopus.com/inward/record.url?scp=18544367202&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1205731

DO - 10.1038/sj.onc.1205731

M3 - Article

C2 - 12203119

VL - 21

SP - 6071

EP - 6081

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 39

ER -