Tris(trimethylsilyl) silane: an unprecedented enhancement in the diastereoselectivity of radical cyclisations to give 2,4-disubstituted piperidines

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Authors

Colleges, School and Institutes

Abstract

Cyclisation of bromides 4a-f mediated by tributyltin hydride affords predominantly the trans piperidines 5a-f with modest diastereomeric ratios, while cyclisation with tris(trimethylsilyl)silane affords the same products with diastereomeric ratios of up to 99:1.

Details

Original languageEnglish
Pages (from-to)2270-2271
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume2
Issue number16
Publication statusPublished - 1 Jan 2004