Tris(trimethylsilyl) silane: an unprecedented enhancement in the diastereoselectivity of radical cyclisations to give 2,4-disubstituted piperidines
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Colleges, School and Institutes
Cyclisation of bromides 4a-f mediated by tributyltin hydride affords predominantly the trans piperidines 5a-f with modest diastereomeric ratios, while cyclisation with tris(trimethylsilyl)silane affords the same products with diastereomeric ratios of up to 99:1.
|Number of pages||2|
|Journal||Organic and Biomolecular Chemistry|
|Publication status||Published - 1 Jan 2004|