Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010

Research output: Contribution to journalArticle

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Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010. / Lamb, Karen E.; Flasche, Stefan; Diggle, Mathew; Inverarity, Donald; Greenhalgh, David; Jefferies, Johanna M.; Smith, Andrew; Edwards, Giles F.s.; Denham, Barbara; Mcmenamin, Jim; Mcdonald, Eisin; Mitchell, Tim J.; Clarke, Stuart C.; Robertson, Chris.

In: Vaccine, Vol. 32, No. 34, 23.07.2014, p. 4356-4363.

Research output: Contribution to journalArticle

Harvard

Lamb, KE, Flasche, S, Diggle, M, Inverarity, D, Greenhalgh, D, Jefferies, JM, Smith, A, Edwards, GFS, Denham, B, Mcmenamin, J, Mcdonald, E, Mitchell, TJ, Clarke, SC & Robertson, C 2014, 'Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010', Vaccine, vol. 32, no. 34, pp. 4356-4363. https://doi.org/10.1016/j.vaccine.2013.05.079

APA

Lamb, K. E., Flasche, S., Diggle, M., Inverarity, D., Greenhalgh, D., Jefferies, J. M., Smith, A., Edwards, G. F. S., Denham, B., Mcmenamin, J., Mcdonald, E., Mitchell, T. J., Clarke, S. C., & Robertson, C. (2014). Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010. Vaccine, 32(34), 4356-4363. https://doi.org/10.1016/j.vaccine.2013.05.079

Vancouver

Lamb KE, Flasche S, Diggle M, Inverarity D, Greenhalgh D, Jefferies JM et al. Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010. Vaccine. 2014 Jul 23;32(34):4356-4363. https://doi.org/10.1016/j.vaccine.2013.05.079

Author

Lamb, Karen E. ; Flasche, Stefan ; Diggle, Mathew ; Inverarity, Donald ; Greenhalgh, David ; Jefferies, Johanna M. ; Smith, Andrew ; Edwards, Giles F.s. ; Denham, Barbara ; Mcmenamin, Jim ; Mcdonald, Eisin ; Mitchell, Tim J. ; Clarke, Stuart C. ; Robertson, Chris. / Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010. In: Vaccine. 2014 ; Vol. 32, No. 34. pp. 4356-4363.

Bibtex

@article{22bd9a1c7e554a379960e9a11a4161d3,
title = "Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010",
abstract = "IntroductionThe 7-valent pneumococcal conjugate vaccine (Prevenar{\textregistered}, Wyeth; PCV7) was introduced to the UK paediatric immunisation schedule in 2006. This study investigates trends in serotypes and multi locus sequence types (STs) among cases of invasive pneumococcal disease (IPD) in Scotland prior to, and following, the introduction of PCV7.MethodsScottish Invasive Pneumococcal Disease Enhanced Surveillance has records of all cases of IPD in Scotland since 1999. Cases diagnosed from blood or cerebrospinal fluid isolates until 2010 were analysed. Logistic and poisson regression modelling was used to assess trends prior to and following the introduction of PCV7.ResultsPrior to PCV7 use, on average 650 cases of IPD were reported each year; 12% occurred in those aged <5 years and 35% affected those aged over 65 years. Serotypes in PCV7 represented 47% of cases (68% in <5 year olds). The serotype and ST distribution was relatively stable with only serotype 1 and associated ST 306 showing an increasing trend. PCV7 introduction was associated with a 69% (95% CI: 50%, 80%) reduction in the incidence of IPD among those aged <5 years, a 57% (95% CI: 47%, 66%) reduction among those aged 5–64 years but no significant change among those aged 65 years and over where increases in non-PCV7 serotypes were observed. Serotypes which became more prevalent post-PCV7 are those which were associated with STs related to the PCV7 serotypes.ConclusionsRoutine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.",
keywords = "Invasive pneumococcal disease, PCV7, Serotype, Sequence type",
author = "Lamb, {Karen E.} and Stefan Flasche and Mathew Diggle and Donald Inverarity and David Greenhalgh and Jefferies, {Johanna M.} and Andrew Smith and Edwards, {Giles F.s.} and Barbara Denham and Jim Mcmenamin and Eisin Mcdonald and Mitchell, {Tim J.} and Clarke, {Stuart C.} and Chris Robertson",
year = "2014",
month = jul,
day = "23",
doi = "10.1016/j.vaccine.2013.05.079",
language = "English",
volume = "32",
pages = "4356--4363",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "34",

}

RIS

TY - JOUR

T1 - Trends in serotypes and sequence types among cases of invasive pneumococcal disease in Scotland, 1999–2010

AU - Lamb, Karen E.

AU - Flasche, Stefan

AU - Diggle, Mathew

AU - Inverarity, Donald

AU - Greenhalgh, David

AU - Jefferies, Johanna M.

AU - Smith, Andrew

AU - Edwards, Giles F.s.

AU - Denham, Barbara

AU - Mcmenamin, Jim

AU - Mcdonald, Eisin

AU - Mitchell, Tim J.

AU - Clarke, Stuart C.

AU - Robertson, Chris

PY - 2014/7/23

Y1 - 2014/7/23

N2 - IntroductionThe 7-valent pneumococcal conjugate vaccine (Prevenar®, Wyeth; PCV7) was introduced to the UK paediatric immunisation schedule in 2006. This study investigates trends in serotypes and multi locus sequence types (STs) among cases of invasive pneumococcal disease (IPD) in Scotland prior to, and following, the introduction of PCV7.MethodsScottish Invasive Pneumococcal Disease Enhanced Surveillance has records of all cases of IPD in Scotland since 1999. Cases diagnosed from blood or cerebrospinal fluid isolates until 2010 were analysed. Logistic and poisson regression modelling was used to assess trends prior to and following the introduction of PCV7.ResultsPrior to PCV7 use, on average 650 cases of IPD were reported each year; 12% occurred in those aged <5 years and 35% affected those aged over 65 years. Serotypes in PCV7 represented 47% of cases (68% in <5 year olds). The serotype and ST distribution was relatively stable with only serotype 1 and associated ST 306 showing an increasing trend. PCV7 introduction was associated with a 69% (95% CI: 50%, 80%) reduction in the incidence of IPD among those aged <5 years, a 57% (95% CI: 47%, 66%) reduction among those aged 5–64 years but no significant change among those aged 65 years and over where increases in non-PCV7 serotypes were observed. Serotypes which became more prevalent post-PCV7 are those which were associated with STs related to the PCV7 serotypes.ConclusionsRoutine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.

AB - IntroductionThe 7-valent pneumococcal conjugate vaccine (Prevenar®, Wyeth; PCV7) was introduced to the UK paediatric immunisation schedule in 2006. This study investigates trends in serotypes and multi locus sequence types (STs) among cases of invasive pneumococcal disease (IPD) in Scotland prior to, and following, the introduction of PCV7.MethodsScottish Invasive Pneumococcal Disease Enhanced Surveillance has records of all cases of IPD in Scotland since 1999. Cases diagnosed from blood or cerebrospinal fluid isolates until 2010 were analysed. Logistic and poisson regression modelling was used to assess trends prior to and following the introduction of PCV7.ResultsPrior to PCV7 use, on average 650 cases of IPD were reported each year; 12% occurred in those aged <5 years and 35% affected those aged over 65 years. Serotypes in PCV7 represented 47% of cases (68% in <5 year olds). The serotype and ST distribution was relatively stable with only serotype 1 and associated ST 306 showing an increasing trend. PCV7 introduction was associated with a 69% (95% CI: 50%, 80%) reduction in the incidence of IPD among those aged <5 years, a 57% (95% CI: 47%, 66%) reduction among those aged 5–64 years but no significant change among those aged 65 years and over where increases in non-PCV7 serotypes were observed. Serotypes which became more prevalent post-PCV7 are those which were associated with STs related to the PCV7 serotypes.ConclusionsRoutine serotyping and sequence typing in Scotland allowed the assessment of the relationship between the capsule and the clones in the post vaccination era. Changes in the distribution of serotypes post PCV7 introduction appear to be driven by associations between serotypes and STs prior to PCV7 introduction. This has implications for the possible effects of the introduction of higher valency vaccines and could aid in predicting replacement serotypes in IPD.

KW - Invasive pneumococcal disease

KW - PCV7

KW - Serotype

KW - Sequence type

U2 - 10.1016/j.vaccine.2013.05.079

DO - 10.1016/j.vaccine.2013.05.079

M3 - Article

C2 - 23806244

VL - 32

SP - 4356

EP - 4363

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 34

ER -