Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development

J.A. King; F.E. Underwood; N. Panaccione; J. Quan; J.W. Windsor; P.G. Kotze; S.C. Ng; S. Ghosh; P.L. Lakatos; T. Jess; R. Panaccione; C.H. Seow; S. Ben-Horin; J. Burisch; J.-F. Colombel; E.V. Loftus; R. Gearry; J. Halfvarson; G.G. Kaplan

doi:10.1016/S2468-1253(19)30013-5

Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development

J.A. King, F.E. Underwood, N. Panaccione, J. Quan, J.W. Windsor, P.G. Kotze, S.C. Ng, S. Ghosh, P.L. Lakatos, T. Jess, R. Panaccione, C.H. Seow, S. Ben-Horin, J. Burisch, J.-F. Colombel, E.V. Loftus, R. Gearry, J. Halfvarson, G.G. Kaplan

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

BACKGROUND: Hospitalisation rates for inflammatory bowel disease (IBD) vary across the world. We aimed to investigate temporal patterns of hospitalisation for IBD in member countries of the Organisation for Economic Co-operation and Development (OECD).

METHODS: From the OECD database, we assessed IBD-related hospitalisation rates (expressed as annual rates per 100 000 inhabitants) for 34 countries from 1990 to 2016. We calculated mean hospitalisation rates for the period 2010-15 and used joinpoint regression models to calculate average annual percentage changes with 95% CIs.

FINDINGS: Mean hospitalisation rates for IBD from 2010 to 2015 were highest in North America (eg, 33·9 per 100 000 in the USA), Europe (eg, 72·9 per 100 000 in Austria), and Oceania (eg, 31·5 per 100 000 in Australia). Hospitalisation rates for IBD were stabilising or decreasing over time in many countries in these regions but increasing in others. Countries in Asia and Latin America and the Caribbean had the lowest IBD-related hospitalisation rates but the greatest increases in rates over time. For example, Turkey had an annual hospitalisation rate of 10·8 per 100 000 inhabitants and an average annual percentage change of 10·4% (95% CI 5·2-15·9). Similarly, Chile had an annual hospitalisation rate of 9·0 per 100 000 inhabitants and an average annual percentage change of 5·9% (4·9-7·0).

INTERPRETATION: Hospitalisation rates for IBD are high in western countries but are typically stabilising or decreasing, whereas rates in many newly industrialised countries are rapidly increasing, which reflects the known increase in IBD prevalence in these countries. Potential explanations for these trends include changes in the epidemiology of IBD, health-care delivery, and infrastructure in these countries, as well as overall country-specific patterns in hospitalisations and differences between countries in data collection methods.

FUNDING: None.

Original language	English
Pages (from-to)	287-295
Number of pages	9
Journal	The Lancet Gastroenterology & Hepatology
Volume	4
Issue number	4
Early online date	12 Feb 2019
DOIs	https://doi.org/10.1016/S2468-1253(19)30013-5
Publication status	Published - 1 Apr 2019

Bibliographical note

ASJC Scopus subject areas

Hepatology
Gastroenterology

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King, J. A., Underwood, F. E., Panaccione, N., Quan, J., Windsor, J. W., Kotze, P. G., Ng, S. C., Ghosh, S., Lakatos, P. L., Jess, T., Panaccione, R., Seow, C. H., Ben-Horin, S., Burisch, J., Colombel, J-F., Loftus, E. V., Gearry, R., Halfvarson, J., & Kaplan, G. G. (2019). Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development. The Lancet Gastroenterology & Hepatology, 4(4), 287-295. Advance online publication. https://doi.org/10.1016/S2468-1253(19)30013-5

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abstract = "BACKGROUND: Hospitalisation rates for inflammatory bowel disease (IBD) vary across the world. We aimed to investigate temporal patterns of hospitalisation for IBD in member countries of the Organisation for Economic Co-operation and Development (OECD).METHODS: From the OECD database, we assessed IBD-related hospitalisation rates (expressed as annual rates per 100 000 inhabitants) for 34 countries from 1990 to 2016. We calculated mean hospitalisation rates for the period 2010-15 and used joinpoint regression models to calculate average annual percentage changes with 95% CIs.FINDINGS: Mean hospitalisation rates for IBD from 2010 to 2015 were highest in North America (eg, 33·9 per 100 000 in the USA), Europe (eg, 72·9 per 100 000 in Austria), and Oceania (eg, 31·5 per 100 000 in Australia). Hospitalisation rates for IBD were stabilising or decreasing over time in many countries in these regions but increasing in others. Countries in Asia and Latin America and the Caribbean had the lowest IBD-related hospitalisation rates but the greatest increases in rates over time. For example, Turkey had an annual hospitalisation rate of 10·8 per 100 000 inhabitants and an average annual percentage change of 10·4% (95% CI 5·2-15·9). Similarly, Chile had an annual hospitalisation rate of 9·0 per 100 000 inhabitants and an average annual percentage change of 5·9% (4·9-7·0).INTERPRETATION: Hospitalisation rates for IBD are high in western countries but are typically stabilising or decreasing, whereas rates in many newly industrialised countries are rapidly increasing, which reflects the known increase in IBD prevalence in these countries. Potential explanations for these trends include changes in the epidemiology of IBD, health-care delivery, and infrastructure in these countries, as well as overall country-specific patterns in hospitalisations and differences between countries in data collection methods.FUNDING: None.",

author = "J.A. King and F.E. Underwood and N. Panaccione and J. Quan and J.W. Windsor and P.G. Kotze and S.C. Ng and S. Ghosh and P.L. Lakatos and T. Jess and R. Panaccione and C.H. Seow and S. Ben-Horin and J. Burisch and J.-F. Colombel and E.V. Loftus and R. Gearry and J. Halfvarson and G.G. Kaplan",

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King, JA, Underwood, FE, Panaccione, N, Quan, J, Windsor, JW, Kotze, PG, Ng, SC, Ghosh, S, Lakatos, PL, Jess, T, Panaccione, R, Seow, CH, Ben-Horin, S, Burisch, J, Colombel, J-F, Loftus, EV, Gearry, R, Halfvarson, J & Kaplan, GG 2019, 'Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development', The Lancet Gastroenterology & Hepatology, vol. 4, no. 4, pp. 287-295. https://doi.org/10.1016/S2468-1253(19)30013-5

Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development. / King, J.A.; Underwood, F.E.; Panaccione, N. et al.
In: The Lancet Gastroenterology & Hepatology, Vol. 4, No. 4, 01.04.2019, p. 287-295.

Research output: Contribution to journal › Article › peer-review

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AU - Panaccione, N.

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AU - Ng, S.C.

AU - Ghosh, S.

AU - Lakatos, P.L.

AU - Jess, T.

AU - Panaccione, R.

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N2 - BACKGROUND: Hospitalisation rates for inflammatory bowel disease (IBD) vary across the world. We aimed to investigate temporal patterns of hospitalisation for IBD in member countries of the Organisation for Economic Co-operation and Development (OECD).METHODS: From the OECD database, we assessed IBD-related hospitalisation rates (expressed as annual rates per 100 000 inhabitants) for 34 countries from 1990 to 2016. We calculated mean hospitalisation rates for the period 2010-15 and used joinpoint regression models to calculate average annual percentage changes with 95% CIs.FINDINGS: Mean hospitalisation rates for IBD from 2010 to 2015 were highest in North America (eg, 33·9 per 100 000 in the USA), Europe (eg, 72·9 per 100 000 in Austria), and Oceania (eg, 31·5 per 100 000 in Australia). Hospitalisation rates for IBD were stabilising or decreasing over time in many countries in these regions but increasing in others. Countries in Asia and Latin America and the Caribbean had the lowest IBD-related hospitalisation rates but the greatest increases in rates over time. For example, Turkey had an annual hospitalisation rate of 10·8 per 100 000 inhabitants and an average annual percentage change of 10·4% (95% CI 5·2-15·9). Similarly, Chile had an annual hospitalisation rate of 9·0 per 100 000 inhabitants and an average annual percentage change of 5·9% (4·9-7·0).INTERPRETATION: Hospitalisation rates for IBD are high in western countries but are typically stabilising or decreasing, whereas rates in many newly industrialised countries are rapidly increasing, which reflects the known increase in IBD prevalence in these countries. Potential explanations for these trends include changes in the epidemiology of IBD, health-care delivery, and infrastructure in these countries, as well as overall country-specific patterns in hospitalisations and differences between countries in data collection methods.FUNDING: None.

AB - BACKGROUND: Hospitalisation rates for inflammatory bowel disease (IBD) vary across the world. We aimed to investigate temporal patterns of hospitalisation for IBD in member countries of the Organisation for Economic Co-operation and Development (OECD).METHODS: From the OECD database, we assessed IBD-related hospitalisation rates (expressed as annual rates per 100 000 inhabitants) for 34 countries from 1990 to 2016. We calculated mean hospitalisation rates for the period 2010-15 and used joinpoint regression models to calculate average annual percentage changes with 95% CIs.FINDINGS: Mean hospitalisation rates for IBD from 2010 to 2015 were highest in North America (eg, 33·9 per 100 000 in the USA), Europe (eg, 72·9 per 100 000 in Austria), and Oceania (eg, 31·5 per 100 000 in Australia). Hospitalisation rates for IBD were stabilising or decreasing over time in many countries in these regions but increasing in others. Countries in Asia and Latin America and the Caribbean had the lowest IBD-related hospitalisation rates but the greatest increases in rates over time. For example, Turkey had an annual hospitalisation rate of 10·8 per 100 000 inhabitants and an average annual percentage change of 10·4% (95% CI 5·2-15·9). Similarly, Chile had an annual hospitalisation rate of 9·0 per 100 000 inhabitants and an average annual percentage change of 5·9% (4·9-7·0).INTERPRETATION: Hospitalisation rates for IBD are high in western countries but are typically stabilising or decreasing, whereas rates in many newly industrialised countries are rapidly increasing, which reflects the known increase in IBD prevalence in these countries. Potential explanations for these trends include changes in the epidemiology of IBD, health-care delivery, and infrastructure in these countries, as well as overall country-specific patterns in hospitalisations and differences between countries in data collection methods.FUNDING: None.

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King JA, Underwood FE, Panaccione N, Quan J, Windsor JW, Kotze PG et al. Trends in hospitalisation rates for inflammatory bowel disease in western versus newly industrialised countries: a population-based study of countries in the Organisation for Economic Co-operation and Development. The Lancet Gastroenterology & Hepatology. 2019 Apr 1;4(4):287-295. Epub 2019 Feb 12. doi: 10.1016/S2468-1253(19)30013-5