Treatment preferences for preventive interventions for rheumatoid arthritis: protocol of a mixed methods case study for the innovative medicines initiative PREFER project

Research output: Contribution to journalArticlepeer-review

Standard

Treatment preferences for preventive interventions for rheumatoid arthritis : protocol of a mixed methods case study for the innovative medicines initiative PREFER project. / Falahee, Marie; Simons, Gwenda; DiSantostefano, Rachael; valor-mendez, larissa; Radawski, Christine; Englbrecht, Matthias; Bywall, Karin; Tcherny-Lessenot, Stephanie; Kihlbom, Ulrik; Hauber, Brett; Veldwijk, Jorien; Raza, Karim.

In: BMJ open, Vol. 11, No. 4, e045851, 08.04.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Falahee, M, Simons, G, DiSantostefano, R, valor-mendez, L, Radawski, C, Englbrecht, M, Bywall, K, Tcherny-Lessenot, S, Kihlbom, U, Hauber, B, Veldwijk, J & Raza, K 2021, 'Treatment preferences for preventive interventions for rheumatoid arthritis: protocol of a mixed methods case study for the innovative medicines initiative PREFER project', BMJ open, vol. 11, no. 4, e045851. https://doi.org/10.1136/bmjopen-2020-045851

APA

Falahee, M., Simons, G., DiSantostefano, R., valor-mendez, L., Radawski, C., Englbrecht, M., Bywall, K., Tcherny-Lessenot, S., Kihlbom, U., Hauber, B., Veldwijk, J., & Raza, K. (2021). Treatment preferences for preventive interventions for rheumatoid arthritis: protocol of a mixed methods case study for the innovative medicines initiative PREFER project. BMJ open, 11(4), [e045851]. https://doi.org/10.1136/bmjopen-2020-045851

Vancouver

Author

Falahee, Marie ; Simons, Gwenda ; DiSantostefano, Rachael ; valor-mendez, larissa ; Radawski, Christine ; Englbrecht, Matthias ; Bywall, Karin ; Tcherny-Lessenot, Stephanie ; Kihlbom, Ulrik ; Hauber, Brett ; Veldwijk, Jorien ; Raza, Karim. / Treatment preferences for preventive interventions for rheumatoid arthritis : protocol of a mixed methods case study for the innovative medicines initiative PREFER project. In: BMJ open. 2021 ; Vol. 11, No. 4.

Bibtex

@article{c2a42ed5c8c743c3ae41d6256144abcd,
title = "Treatment preferences for preventive interventions for rheumatoid arthritis: protocol of a mixed methods case study for the innovative medicines initiative PREFER project",
abstract = "Introduction:Amidst growing consensus that stakeholder decision-making during drug development should be informed by an understanding of patient preferences, The Innovative Medicines Initiative project {\textquoteleft}Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (PREFER) is developing evidence-based recommendations about how and when patient preferences should be integrated into the drug lifecycle. This protocol describes a PREFER clinical case study which compares two preference elicitation methodologies across several populations and provides information about benefit-risk trade-offs by those at risk of rheumatoid arthritis (RA) for preventive interventions.Methods and analysis:This mixed-methods study will be conducted in three countries (UK, Germany, Romania) to assess preferences of a) first degree relatives (FDRs) of patients with RA, and b) members of the public. Focus groups using nominal group techniques (UK) and ranking surveys (Germany and Romania) will identify and rank key treatment attributes. Focus group transcripts will be analyzed thematically using the framework method, and average rank orders calculated. These results will inform the treatment attributes to be assessed in a survey including a discrete choice experiment (DCE) and a probabilistic threshold technique (PTT). The survey will also include measures of sociodemographic variables, health literacy, numeracy, illness perceptions and beliefs about medicines. The survey will be administered to a) 400 FDRs of RA patients (UK); b) 100 FDRs of RA patients (Germany); c) 1000 members of the public in each of the UK, Germany and Romania. Logit-based approaches will be used to analyze the DCE, and imputation and interval regression for the PTT.Ethics and Dissemination:This study has been approved by the London-Hampstead Research Ethics Committee (19/LO/0407), and the Ethics Committee of the Friedrich-Alexander-Universit{\"a}t Erlangen-N{\"u}rnberg (92_17 B). The protocol has been approved by the PREFER expert review board. The results will be disseminated widely, and will inform the PREFER recommendations. ",
author = "Marie Falahee and Gwenda Simons and Rachael DiSantostefano and larissa valor-mendez and Christine Radawski and Matthias Englbrecht and Karin Bywall and Stephanie Tcherny-Lessenot and Ulrik Kihlbom and Brett Hauber and Jorien Veldwijk and Karim Raza",
year = "2021",
month = apr,
day = "8",
doi = "10.1136/bmjopen-2020-045851",
language = "English",
volume = "11",
journal = "BMJ open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Treatment preferences for preventive interventions for rheumatoid arthritis

T2 - protocol of a mixed methods case study for the innovative medicines initiative PREFER project

AU - Falahee, Marie

AU - Simons, Gwenda

AU - DiSantostefano, Rachael

AU - valor-mendez, larissa

AU - Radawski, Christine

AU - Englbrecht, Matthias

AU - Bywall, Karin

AU - Tcherny-Lessenot, Stephanie

AU - Kihlbom, Ulrik

AU - Hauber, Brett

AU - Veldwijk, Jorien

AU - Raza, Karim

PY - 2021/4/8

Y1 - 2021/4/8

N2 - Introduction:Amidst growing consensus that stakeholder decision-making during drug development should be informed by an understanding of patient preferences, The Innovative Medicines Initiative project ‘Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (PREFER) is developing evidence-based recommendations about how and when patient preferences should be integrated into the drug lifecycle. This protocol describes a PREFER clinical case study which compares two preference elicitation methodologies across several populations and provides information about benefit-risk trade-offs by those at risk of rheumatoid arthritis (RA) for preventive interventions.Methods and analysis:This mixed-methods study will be conducted in three countries (UK, Germany, Romania) to assess preferences of a) first degree relatives (FDRs) of patients with RA, and b) members of the public. Focus groups using nominal group techniques (UK) and ranking surveys (Germany and Romania) will identify and rank key treatment attributes. Focus group transcripts will be analyzed thematically using the framework method, and average rank orders calculated. These results will inform the treatment attributes to be assessed in a survey including a discrete choice experiment (DCE) and a probabilistic threshold technique (PTT). The survey will also include measures of sociodemographic variables, health literacy, numeracy, illness perceptions and beliefs about medicines. The survey will be administered to a) 400 FDRs of RA patients (UK); b) 100 FDRs of RA patients (Germany); c) 1000 members of the public in each of the UK, Germany and Romania. Logit-based approaches will be used to analyze the DCE, and imputation and interval regression for the PTT.Ethics and Dissemination:This study has been approved by the London-Hampstead Research Ethics Committee (19/LO/0407), and the Ethics Committee of the Friedrich-Alexander-Universität Erlangen-Nürnberg (92_17 B). The protocol has been approved by the PREFER expert review board. The results will be disseminated widely, and will inform the PREFER recommendations.

AB - Introduction:Amidst growing consensus that stakeholder decision-making during drug development should be informed by an understanding of patient preferences, The Innovative Medicines Initiative project ‘Patient Preferences in Benefit-Risk Assessments during the Drug Life Cycle (PREFER) is developing evidence-based recommendations about how and when patient preferences should be integrated into the drug lifecycle. This protocol describes a PREFER clinical case study which compares two preference elicitation methodologies across several populations and provides information about benefit-risk trade-offs by those at risk of rheumatoid arthritis (RA) for preventive interventions.Methods and analysis:This mixed-methods study will be conducted in three countries (UK, Germany, Romania) to assess preferences of a) first degree relatives (FDRs) of patients with RA, and b) members of the public. Focus groups using nominal group techniques (UK) and ranking surveys (Germany and Romania) will identify and rank key treatment attributes. Focus group transcripts will be analyzed thematically using the framework method, and average rank orders calculated. These results will inform the treatment attributes to be assessed in a survey including a discrete choice experiment (DCE) and a probabilistic threshold technique (PTT). The survey will also include measures of sociodemographic variables, health literacy, numeracy, illness perceptions and beliefs about medicines. The survey will be administered to a) 400 FDRs of RA patients (UK); b) 100 FDRs of RA patients (Germany); c) 1000 members of the public in each of the UK, Germany and Romania. Logit-based approaches will be used to analyze the DCE, and imputation and interval regression for the PTT.Ethics and Dissemination:This study has been approved by the London-Hampstead Research Ethics Committee (19/LO/0407), and the Ethics Committee of the Friedrich-Alexander-Universität Erlangen-Nürnberg (92_17 B). The protocol has been approved by the PREFER expert review board. The results will be disseminated widely, and will inform the PREFER recommendations.

U2 - 10.1136/bmjopen-2020-045851

DO - 10.1136/bmjopen-2020-045851

M3 - Article

VL - 11

JO - BMJ open

JF - BMJ open

SN - 2044-6055

IS - 4

M1 - e045851

ER -