Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe

Research output: Contribution to journalArticlepeer-review

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Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe. / James, Glen; Collin, Estelle; Lawrance, Marcus; Mueller, Achim; Podhorna, Jana; Zaremba-Pechmann, Liliana; Rijnbeek, Peter; van der Lei, Johan; Avillach, Paul; Pedersen, Lars; Ansell, David; Pasqua, Alessandro; Mosseveld, Mees; Grosdidier, Solène; Gungabissoon, Usha; Egger, Peter; Stewart, Robert; Celis-Morales, Carlos; Alexander, Myriam; Novak, Gerald; Gordon, Mark Forrest.

In: Social Psychiatry and Psychiatric Epidemiology, 2020.

Research output: Contribution to journalArticlepeer-review

Harvard

James, G, Collin, E, Lawrance, M, Mueller, A, Podhorna, J, Zaremba-Pechmann, L, Rijnbeek, P, van der Lei, J, Avillach, P, Pedersen, L, Ansell, D, Pasqua, A, Mosseveld, M, Grosdidier, S, Gungabissoon, U, Egger, P, Stewart, R, Celis-Morales, C, Alexander, M, Novak, G & Gordon, MF 2020, 'Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe', Social Psychiatry and Psychiatric Epidemiology. https://doi.org/10.1007/s00127-020-01872-2

APA

James, G., Collin, E., Lawrance, M., Mueller, A., Podhorna, J., Zaremba-Pechmann, L., Rijnbeek, P., van der Lei, J., Avillach, P., Pedersen, L., Ansell, D., Pasqua, A., Mosseveld, M., Grosdidier, S., Gungabissoon, U., Egger, P., Stewart, R., Celis-Morales, C., Alexander, M., ... Gordon, M. F. (Accepted/In press). Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe. Social Psychiatry and Psychiatric Epidemiology. https://doi.org/10.1007/s00127-020-01872-2

Vancouver

Author

James, Glen ; Collin, Estelle ; Lawrance, Marcus ; Mueller, Achim ; Podhorna, Jana ; Zaremba-Pechmann, Liliana ; Rijnbeek, Peter ; van der Lei, Johan ; Avillach, Paul ; Pedersen, Lars ; Ansell, David ; Pasqua, Alessandro ; Mosseveld, Mees ; Grosdidier, Solène ; Gungabissoon, Usha ; Egger, Peter ; Stewart, Robert ; Celis-Morales, Carlos ; Alexander, Myriam ; Novak, Gerald ; Gordon, Mark Forrest. / Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe. In: Social Psychiatry and Psychiatric Epidemiology. 2020.

Bibtex

@article{ccb091a8e650424ab1414c8a4ad44223,
title = "Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe",
abstract = "Purpose: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer{\textquoteright}s Disease. Methods: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. Results: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer{\textquoteright}s disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-d-aspartate blocker memantine in AUH. Conclusion: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer{\textquoteright}s Disease patients from across Europe.",
keywords = "Alzheimer{\textquoteright}s disease, Dementia, Epidemiology, Real-world data",
author = "Glen James and Estelle Collin and Marcus Lawrance and Achim Mueller and Jana Podhorna and Liliana Zaremba-Pechmann and Peter Rijnbeek and {van der Lei}, Johan and Paul Avillach and Lars Pedersen and David Ansell and Alessandro Pasqua and Mees Mosseveld and Sol{\`e}ne Grosdidier and Usha Gungabissoon and Peter Egger and Robert Stewart and Carlos Celis-Morales and Myriam Alexander and Gerald Novak and Gordon, {Mark Forrest}",
year = "2020",
doi = "10.1007/s00127-020-01872-2",
language = "English",
journal = "Journal of Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe

AU - James, Glen

AU - Collin, Estelle

AU - Lawrance, Marcus

AU - Mueller, Achim

AU - Podhorna, Jana

AU - Zaremba-Pechmann, Liliana

AU - Rijnbeek, Peter

AU - van der Lei, Johan

AU - Avillach, Paul

AU - Pedersen, Lars

AU - Ansell, David

AU - Pasqua, Alessandro

AU - Mosseveld, Mees

AU - Grosdidier, Solène

AU - Gungabissoon, Usha

AU - Egger, Peter

AU - Stewart, Robert

AU - Celis-Morales, Carlos

AU - Alexander, Myriam

AU - Novak, Gerald

AU - Gordon, Mark Forrest

PY - 2020

Y1 - 2020

N2 - Purpose: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer’s Disease. Methods: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. Results: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer’s disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-d-aspartate blocker memantine in AUH. Conclusion: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer’s Disease patients from across Europe.

AB - Purpose: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer’s Disease. Methods: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. Results: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer’s disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-d-aspartate blocker memantine in AUH. Conclusion: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer’s Disease patients from across Europe.

KW - Alzheimer’s disease

KW - Dementia

KW - Epidemiology

KW - Real-world data

UR - http://www.scopus.com/inward/record.url?scp=85085988074&partnerID=8YFLogxK

U2 - 10.1007/s00127-020-01872-2

DO - 10.1007/s00127-020-01872-2

M3 - Article

AN - SCOPUS:85085988074

JO - Journal of Social Psychiatry and Psychiatric Epidemiology

JF - Journal of Social Psychiatry and Psychiatric Epidemiology

SN - 0933-7954

ER -