Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Research output: Contribution to journalArticle

Authors

  • Tom J Phillips
  • Hannah Scott
  • David A Menassa
  • Ashleigh L Bignell
  • Aman Sood
  • Jude S Morton
  • Takami Akagi
  • Koki Azuma
  • Mark F Rogers
  • Catherine E Gilmore
  • Gareth J Inman
  • Simon Grant
  • Yealin Chung
  • Mais M Aljunaidy
  • Christy-Lynn Cooke
  • Bruno R Steinkraus
  • Andrew Pocklington
  • Angela Logan
  • Gavin P Collett
  • Helena Kemp
  • Peter A Holmans
  • Michael P Murphy
  • Tudor A Fulga
  • Mitsuru Akashi
  • Sandra T Davidge
  • C Patrick Case

Colleges, School and Institutes

External organisations

  • BRISTOL UNIVERSITY
  • Department of Obstetrics and Gynecology and Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, 565-0871, Japan.
  • University of Dundee
  • Department of Obstetrics, Southmead Hospital, Bristol, BS10 5NB, UK.
  • Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
  • Cardiff University
  • MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, CB2 0XY, UK.
  • Nuffield Department of Obstetrics & Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
  • Department of Clinical Biochemistry, Pathology Sciences Laboratory, Southmead Hospital, Bristol, BS10 5NB, UK.

Abstract

Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease. Exposure of cultured neurons to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes. The secretions and plasma contained altered microRNAs whose targets were linked with changes in gene expression in the fetal brain and with human schizophrenia loci. Molecular and morphological changes in vivo and in vitro were prevented by a single dose of MitoQ bound to nanoparticles, which were shown to localise and prevent oxidative stress in the placenta but not in the fetus. We suggest the possibility of developing preventative treatments that target the placenta and not the fetus to reduce risk of psychiatric disease in later life.

Details

Original languageEnglish
Pages (from-to)9079
JournalScientific Reports
Volume7
Issue number1
Early online date22 Aug 2017
Publication statusE-pub ahead of print - 22 Aug 2017

Keywords

  • Journal Article