Treating age-related multimorbidity: the drug discovery challenge

Research output: Contribution to journalReview articlepeer-review


Colleges, School and Institutes

External organisations

  • University of Dundee
  • University Hospitals Birmingham NHS Foundation Trust


Advanced age is the major risk factor for multimorbidity. Current clinical practice treats the individual age-related diseases, resulting in polypharmacy. Thus, targeting the biological processes that drive ageing could prevent both multimorbidity and polypharmacy.

Bibliographic note

Funding Information: C.E. and C.G. are funded by the UK SPINE Knowledge Exchange network . We thank Teresa O’Leary for her help in identifying geroscience-informed trials in the USA. This paper presents independent research supported by the NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social care. Publisher Copyright: © 2020 The Authors Copyright: Copyright 2020 Elsevier B.V., All rights reserved.


Original languageEnglish
Pages (from-to)1403-1415
Number of pages13
JournalDrug Discovery Today
Issue number8
Publication statusPublished - Aug 2020

ASJC Scopus subject areas