Transition between different renal replacement modalities: gaps in knowledge and care - the Integrated Research initiative

Research output: Contribution to journalReview articlepeer-review


  • INTEGRATED group

Colleges, School and Institutes

External organisations

  • Division of Nephrology, University Health Network, Toronto, Ontario, Canada.
  • Yale University
  • Renal Division, Baxter Healthcare Corporation, Deerfield, IL, USA.
  • Renal Unit, RTS Versalles, Cali, Colombia.
  • University of Amsterdam
  • Institute for Global Health, New Delhi, India.
  • Princess Alexandra Hospital, Woolloongabba, Australia.
  • Instituto Nacional de Cardiología, Mexico City, Mexico.
  • Department of Nephrology, Yabuki Hospital, Yamagata, Japan.
  • Australia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia, and University of Adelaide, Adelaide, Australia.
  • Department of Medicine, Division of Nephrology, University of Missouri, Columbia, MO, USA.
  • Manchester University Hospitals NHS Foundation Trust
  • Nephrology, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
  • Department of Medicine, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, QC, Canada.
  • Arbor Research Collaborative for Health, Ann Arbor, MI, USA.
  • Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea.
  • Division of Nephrology, Department of Medicine & Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
  • Nephrology Department, University of Michigan, Ann Arbor, MI, USA.
  • The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
  • The Chinese University of Hong Kong
  • Ghent University Hospital, Ghent, Belgium
  • Keele University
  • University Hospitals of North Midlands, Stoke-on-Trent, UK


Patients with end-stage kidney disease (ESKD) have different options to replace the function of their failing kidneys. The "integrated care" model considers treatment pathways rather than individual renal replacement therapy (RRT) techniques. In such a paradigm, the optimal strategy to plan and enact transitions between the different modalities is very relevant, but so far, only limited data on transitions have been published. Perspectives of patients, caregivers, and health professionals on the process of transitioning are even less well documented. Available literature suggests that poor coordination causes significant morbidity and mortality.This review briefly provides the background, development, and scope of the INTErnational Group Research Assessing Transition Effects in Dialysis (INTEGRATED) initiative. We summarize the literature on the transition between different RRT modalities. Further, we present an international research plan to quantify the epidemiology and to assess the qualitative aspects of transition between different modalities.

Bibliographic note

Copyright © 2019 International Society for Peritoneal Dialysis.


Original languageEnglish
Pages (from-to)4-12
Number of pages9
JournalPeritoneal Dialysis International
Issue number1
Publication statusPublished - 30 Jan 2019


  • barriers, collaboration, Integrated care, international, patient beliefs, planned/unplanned transitions

ASJC Scopus subject areas