Transient Abnormal Myelopoiesis Associated with Down Syndrome Presenting as Severe Hydrops Fetalis: A Case Report

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We present a case of transient abnormal myelopoiesis (TAM) presenting as non-immune fetal hydrops (NIHF). Hydrops fetalis (HF) is a condition associated with very high perinatal mortality, especially when no treatable cause, such as fetal anaemia, exists. In fetuses prior to 24 weeks with NIHF, a chromosomal anomaly is a common association. TAM is a leukaemic condition, almost entirely limited to children with Down syndrome. The presentation of TAM prenatally is unusual but cases may present ultrasonographically with NIHF and associated fetal hepatosplenomegaly. We report a case presenting in this manner with NIHF detected at 29 weeks' gestation and discuss the subsequent diagnosis and management of in utero TAM. Copyright (C) 2010 S. Karger AG, Basel


Original languageEnglish
Pages (from-to)171-173
Number of pages3
JournalFetal Diagnosis and Therapy
Issue number3
Publication statusPublished - 1 Jan 2010


  • Down syndrome, Myelopoiesis, transient abnormal, Hydrops fetalis, Fetal hydrops, non-immune