Abstract
In addition to its activities as a growth factor, recent studies suggest an immunoregulatory role for transforming growth factor-beta (TGF-beta). In this context we have demonstrated that TGF-beta is a potent chemotactic factor in vitro for human T lymphocytes at a concentration of 40 fM and for monocytes at a concentration of 0.4 fM but that it has no chemotactic activity for neutrophils. Furthermore, using an assay of lymphocyte subset chemotaxis we have been able to show that TGF-beta can induce migration of both CD4+ and CD8+ T lymphocytes in vitro. This study provides further evidence that TGF-beta acts as a cytokine, being able to attract T lymphocytes and monocytes to sites of inflammation. Its role in the pathogenesis of inflammatory reactions is likely to be complex.
| Original language | English |
|---|---|
| Pages (from-to) | 609-12 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 147 |
| Issue number | 2 |
| Publication status | Published - 15 Jul 1991 |
Keywords
- Cells, Cultured
- Chemotaxis, Leukocyte
- Dose-Response Relationship, Drug
- Humans
- In Vitro Techniques
- Monocytes
- N-Formylmethionine Leucyl-Phenylalanine
- Neutrophils
- T-Lymphocytes
- Transforming Growth Factor beta