Transformation of brushite to hydroxyapatite and effects of alginate additives

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Transformation of brushite to hydroxyapatite and effects of alginate additives. / Ucar, Seniz; Bjørnøy, Sindre H.; Bassett, David; Strand, Berit L.; Sikorski, Pawel; Andreassen, Jens Petter.

In: Journal of Crystal Growth, Vol. 468, 15.06.2017, p. 774-780.

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Ucar, Seniz ; Bjørnøy, Sindre H. ; Bassett, David ; Strand, Berit L. ; Sikorski, Pawel ; Andreassen, Jens Petter. / Transformation of brushite to hydroxyapatite and effects of alginate additives. In: Journal of Crystal Growth. 2017 ; Vol. 468. pp. 774-780.

Bibtex

@article{7bb7751ec0ab413589240060edc50d7c,
title = "Transformation of brushite to hydroxyapatite and effects of alginate additives",
abstract = "Phase transformations are important processes during mineral formation in both in vivo and in vitro model systems and macromolecules are influential in regulating the mineralization processes. Calcium phosphate mineralized alginate hydrogels are potential candidates for hard tissue engineering applications and transformation of the resorbable calcium phosphate phases to apatitic bone mineral in vivo enhances the success of these composite materials. Here, the transformation of brushite to hydroxyapatite (HA) and the effects of alginate additives on this process are studied by the investigation of supersaturation profiles with HA-seeded and unseeded experiments. This experimental design allows for detailed kinetic interpretation of the transformation reactions and deduction of information on the nucleation stage of HA by evaluating the results of seeded and unseeded experiments together. In the experimental conditions of this work, transformation was controlled by HA growth until the point of near complete brushite dissolution where the growth and dissolution rates were balanced. The presence of alginate additives at low concentration were not highly influential on transformation rates during the growth dominated region but their retardant effect became more pronounced as the dissolution and growth rates reached an equilibrium where both reactions were effective on transformation kinetics. Decoupling of seeded and unseeded transformation experiments suggested that alginate additives retard HA nucleation and this was most evident in the presence of G-block oligomers.",
keywords = "Biocrystallization, Calcium compounds, Minerals, Nucleation",
author = "Seniz Ucar and Bj{\o}rn{\o}y, {Sindre H.} and David Bassett and Strand, {Berit L.} and Pawel Sikorski and Andreassen, {Jens Petter}",
year = "2017",
month = jun,
day = "15",
doi = "10.1016/j.jcrysgro.2016.11.019",
language = "English",
volume = "468",
pages = "774--780",
journal = "Journal of Crystal Growth",
issn = "0022-0248",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Transformation of brushite to hydroxyapatite and effects of alginate additives

AU - Ucar, Seniz

AU - Bjørnøy, Sindre H.

AU - Bassett, David

AU - Strand, Berit L.

AU - Sikorski, Pawel

AU - Andreassen, Jens Petter

PY - 2017/6/15

Y1 - 2017/6/15

N2 - Phase transformations are important processes during mineral formation in both in vivo and in vitro model systems and macromolecules are influential in regulating the mineralization processes. Calcium phosphate mineralized alginate hydrogels are potential candidates for hard tissue engineering applications and transformation of the resorbable calcium phosphate phases to apatitic bone mineral in vivo enhances the success of these composite materials. Here, the transformation of brushite to hydroxyapatite (HA) and the effects of alginate additives on this process are studied by the investigation of supersaturation profiles with HA-seeded and unseeded experiments. This experimental design allows for detailed kinetic interpretation of the transformation reactions and deduction of information on the nucleation stage of HA by evaluating the results of seeded and unseeded experiments together. In the experimental conditions of this work, transformation was controlled by HA growth until the point of near complete brushite dissolution where the growth and dissolution rates were balanced. The presence of alginate additives at low concentration were not highly influential on transformation rates during the growth dominated region but their retardant effect became more pronounced as the dissolution and growth rates reached an equilibrium where both reactions were effective on transformation kinetics. Decoupling of seeded and unseeded transformation experiments suggested that alginate additives retard HA nucleation and this was most evident in the presence of G-block oligomers.

AB - Phase transformations are important processes during mineral formation in both in vivo and in vitro model systems and macromolecules are influential in regulating the mineralization processes. Calcium phosphate mineralized alginate hydrogels are potential candidates for hard tissue engineering applications and transformation of the resorbable calcium phosphate phases to apatitic bone mineral in vivo enhances the success of these composite materials. Here, the transformation of brushite to hydroxyapatite (HA) and the effects of alginate additives on this process are studied by the investigation of supersaturation profiles with HA-seeded and unseeded experiments. This experimental design allows for detailed kinetic interpretation of the transformation reactions and deduction of information on the nucleation stage of HA by evaluating the results of seeded and unseeded experiments together. In the experimental conditions of this work, transformation was controlled by HA growth until the point of near complete brushite dissolution where the growth and dissolution rates were balanced. The presence of alginate additives at low concentration were not highly influential on transformation rates during the growth dominated region but their retardant effect became more pronounced as the dissolution and growth rates reached an equilibrium where both reactions were effective on transformation kinetics. Decoupling of seeded and unseeded transformation experiments suggested that alginate additives retard HA nucleation and this was most evident in the presence of G-block oligomers.

KW - Biocrystallization

KW - Calcium compounds

KW - Minerals

KW - Nucleation

UR - http://www.scopus.com/inward/record.url?scp=85007242077&partnerID=8YFLogxK

U2 - 10.1016/j.jcrysgro.2016.11.019

DO - 10.1016/j.jcrysgro.2016.11.019

M3 - Article

AN - SCOPUS:85007242077

VL - 468

SP - 774

EP - 780

JO - Journal of Crystal Growth

JF - Journal of Crystal Growth

SN - 0022-0248

ER -