Transfer of Stereochemical Information in a Minimal Self-Replicating System

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Transfer of Stereochemical Information in a Minimal Self-Replicating System. / Allen, Victoria; Spencer, Neil; Philp, Douglas.

In: Org. Lett, Vol. 3, 01.01.2001, p. 777-780.

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@article{0a7da1a7cd5145949a2236e05ddac38f,
title = "Transfer of Stereochemical Information in a Minimal Self-Replicating System",
abstract = "[structure: see text]. The rational design, synthesis, and characterization of a minimal self-replicating system based on a 1,3-dipolar cycloaddition between a nitrone and a maleimide is presented. The importance of molecular recognition in this system is demonstrated using a competitive inhibitor. Doping experiments demonstrate that only one of the two diastereoisomeric products of the cycloaddition reaction is capable of acting as an efficient template for its own formation, accelerating the reaction between the nitrone and maleimide and controlling the stereochemical outcome of the reaction.",
author = "Victoria Allen and Neil Spencer and Douglas Philp",
year = "2001",
month = jan,
day = "1",
doi = "10.1021/ol015540v",
language = "English",
volume = "3",
pages = "777--780",
journal = "Org. Lett",

}

RIS

TY - JOUR

T1 - Transfer of Stereochemical Information in a Minimal Self-Replicating System

AU - Allen, Victoria

AU - Spencer, Neil

AU - Philp, Douglas

PY - 2001/1/1

Y1 - 2001/1/1

N2 - [structure: see text]. The rational design, synthesis, and characterization of a minimal self-replicating system based on a 1,3-dipolar cycloaddition between a nitrone and a maleimide is presented. The importance of molecular recognition in this system is demonstrated using a competitive inhibitor. Doping experiments demonstrate that only one of the two diastereoisomeric products of the cycloaddition reaction is capable of acting as an efficient template for its own formation, accelerating the reaction between the nitrone and maleimide and controlling the stereochemical outcome of the reaction.

AB - [structure: see text]. The rational design, synthesis, and characterization of a minimal self-replicating system based on a 1,3-dipolar cycloaddition between a nitrone and a maleimide is presented. The importance of molecular recognition in this system is demonstrated using a competitive inhibitor. Doping experiments demonstrate that only one of the two diastereoisomeric products of the cycloaddition reaction is capable of acting as an efficient template for its own formation, accelerating the reaction between the nitrone and maleimide and controlling the stereochemical outcome of the reaction.

UR - http://www.scopus.com/inward/record.url?scp=0001472589&partnerID=8YFLogxK

U2 - 10.1021/ol015540v

DO - 10.1021/ol015540v

M3 - Article

C2 - 11259060

VL - 3

SP - 777

EP - 780

JO - Org. Lett

JF - Org. Lett

ER -