Transfer of Stereochemical Information in a Minimal Self-Replicating System
Research output: Contribution to journal › Article
Colleges, School and Institutes
[structure: see text]. The rational design, synthesis, and characterization of a minimal self-replicating system based on a 1,3-dipolar cycloaddition between a nitrone and a maleimide is presented. The importance of molecular recognition in this system is demonstrated using a competitive inhibitor. Doping experiments demonstrate that only one of the two diastereoisomeric products of the cycloaddition reaction is capable of acting as an efficient template for its own formation, accelerating the reaction between the nitrone and maleimide and controlling the stereochemical outcome of the reaction.
|Number of pages||4|
|Publication status||Published - 1 Jan 2001|