Transcranial magnetic stimulation of right inferior parietalcortex causally influences prefrontal activation for visualdetection

Research output: Contribution to journalArticle

Authors

  • Uta Noppeney
  • Joana Leitao
  • Axel Thielscher
  • Hweeling Lee
  • Johannes Tuennerhoff

External organisations

  • Cognitive Neuroimaging Group
  • High-field Magnetic Resonance Centre
  • Max Planck Institute for Biological Cybernetics
  • DRCMR, Copenhagen University Hospital Hvidovre
  • German Center for Neurodegenerative Diseases (DZNE)
  • Memory Dysfunction in Neurodegenerative Diseases

Abstract

For effective interactions with the environment, the brain needs to form perceptual decisions based on noisy sensory evidence.Accumulating evidence suggests that perceptual decisions are formed by widespread interactions amongst sensory areas repre-senting the noisy sensory evidence and fronto-parietal areas integrating the evidence into a decision variable that is compared toa decisional threshold. This concurrent transcranial magnetic stimulation (TMS)-fMRI study applied 10 Hz bursts of four TMS (orSham) pulses to the intraparietal sulcus (IPS) to investigate the causal influence of IPS on the neural systems involved in percep-tual decision-making. Participants had to detect visual signals at threshold intensity that were presented in their left lower visualfield on 50% of the trials. Critically, we adjusted the signal strength such that participants failed to detect the visual stimulus onapproximately 30% of the trials allowing us to categorise trials into hits, misses and correct rejections (CR). Our results show thatIPS-relative to Sham-TMS attenuated activation increases for misses relative to CR in the left middle and superior frontal gyri.Critically, while IPS-TMS did not significantly affect participants’ performance accuracy, it affected how observers adjusted theirresponse times after making an error. We therefore suggest that activation increases in superior frontal gyri for misses relative tocorrect responses may not be critical for signal detection performance, but rather reflect post-decisional processing such asmetacognitive monitoring of choice accuracy or decisional confidence.

Details

Original languageEnglish
Pages (from-to)2807-2816
JournalEuropean Journal of Neuroscience
Volume46
Issue number12
Early online date6 Nov 2017
Publication statusPublished - Dec 2017