Abstract
This article describes the uses of immunostaining in the diagnosis of cholestasis To immunostain for bile salt export pump (BSEP) and multidrug resistance protein 3 in severe hepatobiliary disease manifest early in life can rapidly identify whether sequencing of ABCB11 or ABCB4 is likely to yield a genetic diagnosis To immunostain for canalicular ectoenzymes as well as transporters with transmission electron microscopy can suggest whether sequencing of ATP8B1 is likely to yield a genetic diagnosis Demonstrating BSEP expression can direct attention to bile acid synthesis disorders Immunostaining for multidrug resistance-associated protein 2 serves principally as a control for adequacy of processing
Original language | English |
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Pages (from-to) | 619-+ |
Journal | Clinics in Liver Disease |
Volume | 14 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Nov 2010 |
Keywords
- Multidrug resistance protein
- Genetic diagnosis
- Pediatric cholestasis
- Cell polarity
- Bile salt export pump