Tracking genomic cancer evolution for precision medicine : the lung TRACERx study

Mariam Jamal-hanjani; Alan Hackshaw; Yenting Ngai; Jacqueline Shaw; Caroline Dive; Sergio Quezada; Gary Middleton; Elza De Bruin; John Le Quesne; Seema Shafi; Mary Falzon; Stuart Horswell; Fiona Blackhall; Iftekhar Khan; Sam Janes; Marianne Nicolson; David Lawrence; Martin Forster; Dean Fennell; Siow-ming Lee; Jason Lester; Keith Kerr; Salli Muller; Natasha Iles; Sean Smith; Nirupa Murugaesu; Richard Mitter; Max Salm; Aengus Stuart; Nik Matthews; Haydn Adams; Tanya Ahmad; Richard Attanoos; Jonathan Bennett; Nicolai Juul Birkbak; Richard Booton; Ged Brady; Keith Buchan; Arrigo Capitano; Mahendran Chetty; Mark Cobbold; Philip Crosbie; Helen Davies; Alan Denison; Madhav Djearman; Jacki Goldman; Tom Haswell; Leena Joseph; Malgorzata Kornaszewska; Matthew Krebs; Gerald Langman; Mairead Mackenzie; Joy Millar; Bruno Morgan; Babu Naidu; Daisuke Nonaka; Karl Peggs; Catrin Pritchard; Hardy Remmen; Andrew Rowan; Rajesh Shah; Elaine Smith; Yvonne Summers; Magali Taylor; Selvaraju Veeriah; David Waller; Ben Wilcox; Maggie Wilcox; Ian Woolhouse; Nicholas Mcgranahan; Charles Swanton

doi:10.1371/journal.pbio.1001906

Tracking genomic cancer evolution for precision medicine : the lung TRACERx study

Mariam Jamal-hanjani, Alan Hackshaw, Yenting Ngai, Jacqueline Shaw, Caroline Dive, Sergio Quezada, Gary Middleton, Elza De Bruin, John Le Quesne, Seema Shafi, Mary Falzon, Stuart Horswell, Fiona Blackhall, Iftekhar Khan, Sam Janes, Marianne Nicolson, David Lawrence, Martin Forster, Dean Fennell, Siow-ming LeeJason Lester, Keith Kerr, Salli Muller, Natasha Iles, Sean Smith, Nirupa Murugaesu, Richard Mitter, Max Salm, Aengus Stuart, Nik Matthews, Haydn Adams, Tanya Ahmad, Richard Attanoos, Jonathan Bennett, Nicolai Juul Birkbak, Richard Booton, Ged Brady, Keith Buchan, Arrigo Capitano, Mahendran Chetty, Mark Cobbold, Philip Crosbie, Helen Davies, Alan Denison, Madhav Djearman, Jacki Goldman, Tom Haswell, Leena Joseph, Malgorzata Kornaszewska, Matthew Krebs, Gerald Langman, Mairead Mackenzie, Joy Millar, Bruno Morgan, Babu Naidu, Daisuke Nonaka, Karl Peggs, Catrin Pritchard, Hardy Remmen, Andrew Rowan, Rajesh Shah, Elaine Smith, Yvonne Summers, Magali Taylor, Selvaraju Veeriah, David Waller, Ben Wilcox, Maggie Wilcox, Ian Woolhouse, Nicholas Mcgranahan, Charles Swanton

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Abstract

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

Original language	English
Article number	e1001906
Journal	PLoS Biology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1371/journal.pbio.1001906
Publication status	Published - 8 Jul 2014

Keywords

Biomarkers
Drug therapy
Evolutionary genetics
Genome evolution
Evolutionary immunology
Genomic medicine
Lung and intrathoracic tumors
Non-small cell lung cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pbio.1001906

Cobbold_Tracking_genomic_cancer_evolution_PLOS_Biology_2014
Eligibility for repository : checked 15/08/2014
Final published version, 701 KBLicence: Creative Commons: Attribution (CC BY)

http://dx.plos.org/10.1371/journal.pbio.1001906

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Jamal-hanjani, M., Hackshaw, A., Ngai, Y., Shaw, J., Dive, C., Quezada, S., Middleton, G., De Bruin, E., Le Quesne, J., Shafi, S., Falzon, M., Horswell, S., Blackhall, F., Khan, I., Janes, S., Nicolson, M., Lawrence, D., Forster, M., Fennell, D., ... Swanton, C. (2014). Tracking genomic cancer evolution for precision medicine : the lung TRACERx study. PLoS Biology, 12(7), Article e1001906. https://doi.org/10.1371/journal.pbio.1001906

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abstract = "The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.",

keywords = "Biomarkers, Drug therapy, Evolutionary genetics, Genome evolution, Evolutionary immunology, Genomic medicine, Lung and intrathoracic tumors, Non-small cell lung cancer",

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Jamal-hanjani, M, Hackshaw, A, Ngai, Y, Shaw, J, Dive, C, Quezada, S, Middleton, G, De Bruin, E, Le Quesne, J, Shafi, S, Falzon, M, Horswell, S, Blackhall, F, Khan, I, Janes, S, Nicolson, M, Lawrence, D, Forster, M, Fennell, D, Lee, S, Lester, J, Kerr, K, Muller, S, Iles, N, Smith, S, Murugaesu, N, Mitter, R, Salm, M, Stuart, A, Matthews, N, Adams, H, Ahmad, T, Attanoos, R, Bennett, J, Birkbak, NJ, Booton, R, Brady, G, Buchan, K, Capitano, A, Chetty, M, Cobbold, M, Crosbie, P, Davies, H, Denison, A, Djearman, M, Goldman, J, Haswell, T, Joseph, L, Kornaszewska, M, Krebs, M, Langman, G, Mackenzie, M, Millar, J, Morgan, B, Naidu, B, Nonaka, D, Peggs, K, Pritchard, C, Remmen, H, Rowan, A, Shah, R, Smith, E, Summers, Y, Taylor, M, Veeriah, S, Waller, D, Wilcox, B, Wilcox, M, Woolhouse, I, Mcgranahan, N & Swanton, C 2014, 'Tracking genomic cancer evolution for precision medicine : the lung TRACERx study', PLoS Biology, vol. 12, no. 7, e1001906. https://doi.org/10.1371/journal.pbio.1001906

TY - JOUR

T1 - Tracking genomic cancer evolution for precision medicine : the lung TRACERx study

AU - Jamal-hanjani, Mariam

AU - Hackshaw, Alan

AU - Ngai, Yenting

AU - Shaw, Jacqueline

AU - Dive, Caroline

AU - Quezada, Sergio

AU - Middleton, Gary

AU - De Bruin, Elza

AU - Le Quesne, John

AU - Shafi, Seema

AU - Falzon, Mary

AU - Horswell, Stuart

AU - Blackhall, Fiona

AU - Khan, Iftekhar

AU - Janes, Sam

AU - Nicolson, Marianne

AU - Lawrence, David

AU - Forster, Martin

AU - Fennell, Dean

AU - Lee, Siow-ming

AU - Lester, Jason

AU - Kerr, Keith

AU - Muller, Salli

AU - Iles, Natasha

AU - Smith, Sean

AU - Murugaesu, Nirupa

AU - Mitter, Richard

AU - Salm, Max

AU - Stuart, Aengus

AU - Matthews, Nik

AU - Adams, Haydn

AU - Ahmad, Tanya

AU - Attanoos, Richard

AU - Bennett, Jonathan

AU - Birkbak, Nicolai Juul

AU - Booton, Richard

AU - Brady, Ged

AU - Buchan, Keith

AU - Capitano, Arrigo

AU - Chetty, Mahendran

AU - Cobbold, Mark

AU - Crosbie, Philip

AU - Davies, Helen

AU - Denison, Alan

AU - Djearman, Madhav

AU - Goldman, Jacki

AU - Haswell, Tom

AU - Joseph, Leena

AU - Kornaszewska, Malgorzata

AU - Krebs, Matthew

AU - Langman, Gerald

AU - Mackenzie, Mairead

AU - Millar, Joy

AU - Morgan, Bruno

AU - Naidu, Babu

AU - Nonaka, Daisuke

AU - Peggs, Karl

AU - Pritchard, Catrin

AU - Remmen, Hardy

AU - Rowan, Andrew

AU - Shah, Rajesh

AU - Smith, Elaine

AU - Summers, Yvonne

AU - Taylor, Magali

AU - Veeriah, Selvaraju

AU - Waller, David

AU - Wilcox, Ben

AU - Wilcox, Maggie

AU - Woolhouse, Ian

AU - Mcgranahan, Nicholas

AU - Swanton, Charles

PY - 2014/7/8

Y1 - 2014/7/8

N2 - The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

AB - The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

KW - Biomarkers

KW - Drug therapy

KW - Evolutionary genetics

KW - Genome evolution

KW - Evolutionary immunology

KW - Genomic medicine

KW - Lung and intrathoracic tumors

KW - Non-small cell lung cancer

U2 - 10.1371/journal.pbio.1001906

DO - 10.1371/journal.pbio.1001906

M3 - Article

C2 - 25003521

SN - 1544-9173

VL - 12

JO - PLoS Biology

JF - PLoS Biology

IS - 7

M1 - e1001906

ER -

Tracking genomic cancer evolution for precision medicine : the lung TRACERx study

Abstract

Keywords

UN SDGs

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