Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.

Peter Jervis; M Moulis; JP Jukes; H Ghadbane; Liam Cox; V Cerundolo; Gurdyal Besra

doi:10.1016/j.carres.2012.02.034

Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.

Peter Jervis, M Moulis, JP Jukes, H Ghadbane, Liam Cox, V Cerundolo, Gurdyal Besra

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Abstract

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.

Original language	English
Journal	Carbohydrate Research
DOIs	https://doi.org/10.1016/j.carres.2012.02.034
Publication status	Published - 7 Mar 2012

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10.1016/j.carres.2012.02.034

Design, synthesis, and assessment of specific iNKT cell agonists for clinical applications
Besra, D., Cox, L., Cunningham, A. & Lammas, T.
Medical Research Council
1/03/12 → 29/02/16
Project: Research Councils

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title = "Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.",

abstract = "A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.",

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AU - Jervis, Peter

AU - Moulis, M

AU - Jukes, JP

AU - Ghadbane, H

AU - Cox, Liam

AU - Cerundolo, V

AU - Besra, Gurdyal

PY - 2012/3/7

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AB - A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.

U2 - 10.1016/j.carres.2012.02.034

DO - 10.1016/j.carres.2012.02.034

M3 - Article

C2 - 22445102

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.

Abstract

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Design, synthesis, and assessment of specific iNKT cell agonists for clinical applications

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