Towards a genomics-informed, real-time, global pathogen surveillance system

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

External organisations

  • School of Population and Public Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

Abstract

The recent Ebola and Zika epidemics demonstrate the need for the continuous surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast, affordable sequencing of pathogen genomes - now a staple of the public health microbiology laboratory in well-resourced settings - can affect each of these areas. Coupling genomic diagnostics and epidemiology to innovative digital disease detection platforms raises the possibility of an open, global, digital pathogen surveillance system. When informed by a One Health approach, in which human, animal and environmental health are considered together, such a genomics-based system has profound potential to improve public health in settings lacking robust laboratory capacity.

Details

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalNature Reviews Genetics
Volume19
Issue number1
Early online date13 Nov 2017
Publication statusPublished - 1 Jan 2018

Keywords

  • Animals, Communicable Diseases, Emerging/epidemiology, Computer Systems, Environmental Health, Epidemics, Genomics, Hemorrhagic Fever, Ebola/epidemiology, High-Throughput Nucleotide Sequencing, Humans, Metagenomics, Models, Biological, Molecular Epidemiology, Public Health, Public Health Surveillance/methods