Tolerance to a haemorrhagic challenge during heat stress is improved with inspiratory resistance breathing

Research output: Contribution to journalArticlepeer-review

Authors

  • Mu Huang
  • Matthew Brothers
  • Matthew Ganio
  • Matthew Cramer
  • Gilbert Moralez
  • Victor Convertino
  • Craig G. Crandall

Colleges, School and Institutes

Abstract

Heat exposure impairs human blood pressure control and markedly reduces tolerance to a simulated haemorrhagic challenge. Inspiratory resistance breathing enhances blood pressure control and improves tolerance during simulated haemorrhage in normothermic individuals. However, it is unknown whether similar improvements occur with this manoeuvre in heat stress conditions. In this study, we tested the hypothesis that inspiratory resistance breathing improves tolerance to simulated haemorrhage in individuals with elevated internal temperatures. On two separate days, eight subjects performed a simulated haemorrhage challenge [lower-body negative pressure (LBNP)] to presyncope after an increase in internal temperature of 1.3 ± 0.1◦C. During one trial, subjects breathed through an inspiratory impedance device set at 0 cmH2O of resistance (Sham), whereas on a subsequent day the device was set at −7 cmH2O of resistance (ITD). Tolerance was quantified as the cumulative stress index. Subjects were more tolerant to the LBNP challenge during the ITD protocol, as indicated by a > 30% larger cumulative stress index (Sham, 520 ± 306 mmHg min; ITD, 682 ± 324 mmHg min; P < 0.01). These data indicate that inspiratory resistance breathing modestly improves tolerance to a simulated progressive haemorrhagic challenge during heat stress.

Details

Original languageEnglish
Pages (from-to)1243-1250
Number of pages8
JournalExperimental Physiology
Volume103
Issue number9
Publication statusPublished - 27 Jun 2018

Keywords

  • inspiratory threshold device, lower-body negative pressure, whole-body heating