Tissue stroma as a regulator of leukocyte recruitment in inflammation

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Tissue stroma as a regulator of leukocyte recruitment in inflammation. / McGettrick, Helen; Butler, Lucilla; Buckley, Christopher; Rainger, Ed; Nash, Gerard.

In: Journal of Leukocyte Biology, Vol. 91, No. 3, 01.03.2012, p. 385-400.

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@article{f0736d197f4e4a609930b1cf86c043f3,
title = "Tissue stroma as a regulator of leukocyte recruitment in inflammation",
abstract = "The stromal milieu (cellular and matrix components) helps establish tissue {"}address-codes{"} that direct leukocyte behavior in inflamed tissue. Coordinated interactions among the stroma, leukocytes, and ECs dictate which leukocytes are recruited, whether they are retained within the inflamed site, and how long they survive. Herein, we discuss how the stromal milieu influences the leukocyte recruitment cascade. Moreover, we explore how corruption of the stromal phenotype in chronic inflammatory diseases contributes to undesired, continuous recruitment of leukocytes. Emerging complex, multicellular, multilayered (co-)culture models are now addressing the molecular circuitry involved in regulating stromal organization during inflammation. Understanding context-specific changes in pro- or anti-inflammatory agents derived from the stroma, such as IL-6 (and its cofactors), is important for the generation of therapeutic strategies that restore the balance between recruitment and clearance of the inflammatory infiltrate in chronic disease.",
author = "Helen McGettrick and Lucilla Butler and Christopher Buckley and Ed Rainger and Gerard Nash",
year = "2012",
month = mar,
day = "1",
doi = "10.1189/jlb.0911458",
language = "English",
volume = "91",
pages = "385--400",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "Society for Leukocyte Biology",
number = "3",

}

RIS

TY - JOUR

T1 - Tissue stroma as a regulator of leukocyte recruitment in inflammation

AU - McGettrick, Helen

AU - Butler, Lucilla

AU - Buckley, Christopher

AU - Rainger, Ed

AU - Nash, Gerard

PY - 2012/3/1

Y1 - 2012/3/1

N2 - The stromal milieu (cellular and matrix components) helps establish tissue "address-codes" that direct leukocyte behavior in inflamed tissue. Coordinated interactions among the stroma, leukocytes, and ECs dictate which leukocytes are recruited, whether they are retained within the inflamed site, and how long they survive. Herein, we discuss how the stromal milieu influences the leukocyte recruitment cascade. Moreover, we explore how corruption of the stromal phenotype in chronic inflammatory diseases contributes to undesired, continuous recruitment of leukocytes. Emerging complex, multicellular, multilayered (co-)culture models are now addressing the molecular circuitry involved in regulating stromal organization during inflammation. Understanding context-specific changes in pro- or anti-inflammatory agents derived from the stroma, such as IL-6 (and its cofactors), is important for the generation of therapeutic strategies that restore the balance between recruitment and clearance of the inflammatory infiltrate in chronic disease.

AB - The stromal milieu (cellular and matrix components) helps establish tissue "address-codes" that direct leukocyte behavior in inflamed tissue. Coordinated interactions among the stroma, leukocytes, and ECs dictate which leukocytes are recruited, whether they are retained within the inflamed site, and how long they survive. Herein, we discuss how the stromal milieu influences the leukocyte recruitment cascade. Moreover, we explore how corruption of the stromal phenotype in chronic inflammatory diseases contributes to undesired, continuous recruitment of leukocytes. Emerging complex, multicellular, multilayered (co-)culture models are now addressing the molecular circuitry involved in regulating stromal organization during inflammation. Understanding context-specific changes in pro- or anti-inflammatory agents derived from the stroma, such as IL-6 (and its cofactors), is important for the generation of therapeutic strategies that restore the balance between recruitment and clearance of the inflammatory infiltrate in chronic disease.

U2 - 10.1189/jlb.0911458

DO - 10.1189/jlb.0911458

M3 - Article

C2 - 22227966

VL - 91

SP - 385

EP - 400

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 3

ER -