Timing of co-phenylcaine administration before rigid nasendoscopy: a randomized, controlled trial

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Colleges, School and Institutes


Rigid nasendoscopy is a commonly used method of examining the nasal cavity and postnasal space. Co-phenylcaine is useful for its vasoconstrictive and anaesthetic properties, but the length of time allowed for it to take effect is variable. We performed a single-blind, randomized, controlled trial to determine whether it was better to allow one or 10 minutes for co-phenylcaine to take effect. Fifty patients were randomized into two groups, 25 in each. Patients in the 10 minute group experienced less discomfort (p=0.02) and less pain (p=0.018) than those in the one minute group. Ease of examination was also greater in the 10 minute group, as was the quality of the image obtained (p<0.001).


Original languageEnglish
Pages (from-to)228-30
Number of pages3
JournalThe Journal of laryngology and otology
Issue number3
Publication statusPublished - Mar 2007


  • Adolescent, Adult, Aged, Aged, 80 and over, Anesthetics, Local, Drug Administration Schedule, Drug Combinations, Endoscopy, Female, Humans, Lidocaine, Male, Middle Aged, Nasal Cavity, Nasal Decongestants, Pain Measurement, Phenylephrine, Single-Blind Method, Time Factors