Time Resolved Diffuse Optical Spectroscopy with Geometrically Accurate Models for Bulk Parameter Recovery

James Guggenheim; Ilaria Bargigia; Andrea  Farina; Antonio Pifferi; Hamid Dehghani

doi:10.1364/BOE.7.003784

Time Resolved Diffuse Optical Spectroscopy with Geometrically Accurate Models for Bulk Parameter Recovery

James Guggenheim, Ilaria Bargigia, Andrea Farina, Antonio Pifferi, Hamid Dehghani

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A novel straightforward, accessible and efficient approach is presented for performing hyperspectral time-domain diffuse optical spectroscopy to determine the optical properties of samples accurately using geometry specific models. To allow bulk parameter recovery from measured spectra, a set of libraries based on a numerical model of the domain being investigated is developed as opposed to the conventional approach of using an analytical semi-infinite slab approximation, which is known and shown to introduce boundary effects. Results demonstrate that the method improves the accuracy of derived spectrally varying optical properties over the use of the semi-infinite approximation.

Original language	English
Pages (from-to)	3784-3794
Number of pages	11
Journal	Biomedical Optics Express
Volume	7
Issue number	9
DOIs	https://doi.org/10.1364/BOE.7.003784
Publication status	Published - 1 Sept 2016

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abstract = "A novel straightforward, accessible and efficient approach is presented for performing hyperspectral time-domain diffuse optical spectroscopy to determine the optical properties of samples accurately using geometry specific models. To allow bulk parameter recovery from measured spectra, a set of libraries based on a numerical model of the domain being investigated is developed as opposed to the conventional approach of using an analytical semi-infinite slab approximation, which is known and shown to introduce boundary effects. Results demonstrate that the method improves the accuracy of derived spectrally varying optical properties over the use of the semi-infinite approximation.",

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AU - Pifferi, Antonio

AU - Dehghani, Hamid

PY - 2016/9/1

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N2 - A novel straightforward, accessible and efficient approach is presented for performing hyperspectral time-domain diffuse optical spectroscopy to determine the optical properties of samples accurately using geometry specific models. To allow bulk parameter recovery from measured spectra, a set of libraries based on a numerical model of the domain being investigated is developed as opposed to the conventional approach of using an analytical semi-infinite slab approximation, which is known and shown to introduce boundary effects. Results demonstrate that the method improves the accuracy of derived spectrally varying optical properties over the use of the semi-infinite approximation.

AB - A novel straightforward, accessible and efficient approach is presented for performing hyperspectral time-domain diffuse optical spectroscopy to determine the optical properties of samples accurately using geometry specific models. To allow bulk parameter recovery from measured spectra, a set of libraries based on a numerical model of the domain being investigated is developed as opposed to the conventional approach of using an analytical semi-infinite slab approximation, which is known and shown to introduce boundary effects. Results demonstrate that the method improves the accuracy of derived spectrally varying optical properties over the use of the semi-infinite approximation.

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DO - 10.1364/BOE.7.003784

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Time Resolved Diffuse Optical Spectroscopy with Geometrically Accurate Models for Bulk Parameter Recovery

Abstract

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