Time Resolved Diffuse Optical Spectroscopy with Geometrically Accurate Models for Bulk Parameter Recovery

Research output: Contribution to journalArticlepeer-review


  • James Guggenheim
  • Ilaria Bargigia
  • Andrea Farina
  • Antonio Pifferi
  • Hamid Dehghani

External organisations

  • University College London
  • Istituto Italiano di Tecnologia, Milano
  • Istituto di Fotonica e Nanotecnologie, Milano
  • Politecnico di Milano


A novel straightforward, accessible and efficient approach is presented for performing hyperspectral time-domain diffuse optical spectroscopy to determine the optical properties of samples accurately using geometry specific models. To allow bulk parameter recovery from measured spectra, a set of libraries based on a numerical model of the domain being investigated is developed as opposed to the conventional approach of using an analytical semi-infinite slab approximation, which is known and shown to introduce boundary effects. Results demonstrate that the method improves the accuracy of derived spectrally varying optical properties over the use of the semi-infinite approximation.


Original languageEnglish
Pages (from-to)3784-3794
Number of pages11
JournalBiomedical Optics Express
Issue number9
Publication statusPublished - 1 Sep 2016